首页> 外文期刊>Bioscience, Biotechnology, and Biochemistry >Suppressive properties of ginsenoside Rb2, a protopanaxadiol-type ginseng saponin, on reactive oxygen species and matrix metalloproteinase-2 in UV-B-irradiated human dermal keratinocytes
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Suppressive properties of ginsenoside Rb2, a protopanaxadiol-type ginseng saponin, on reactive oxygen species and matrix metalloproteinase-2 in UV-B-irradiated human dermal keratinocytes

机译:人参皂苷Rb2,一种原子皂苷型人参皂苷,在反应性氧物质和基质金属蛋白酶-2中的抑制性质,在UV-B辐照人的皮肤蛋白角质形成细胞中

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摘要

Ginsenosides, also known as ginseng saponins, are the principal bioactive ingredients of ginseng, which are responsible for its diverse pharmacological activities. The present work aimed to assess skin anti-photoaging properties of ginsenoside Rb2 (Rb2), one of the predominant protopanaxadiol-type ginsenosides, in human epidermal keratinocyte HaCaT cells under UV-B irradiation. When the cultured keratinocytes were subjected to Rb2 prior to UV-B irradiation, Rb2 displayed suppressive activities on UV-B-induced reactive oxygen species elevation and matrix metalloproteinase-2 expression and secretion. However, Rb2 at the used concentrations was unable to modulate cellular survivals in the UV-B-irradiated keratinocytes. In brief, Rb2 possesses a protective role against the photoaging of human keratinocyte cells under UV-B irradiation.
机译:人参皂苷,也称为人参皂苷,是人参的主要生物活性成分,其负责其各种药理学活动。 目前的作品,用于评估人参皂苷RB2(RB2)的皮肤抗焦特性,在UV-B照射下的人表皮角蛋白酶细胞HaCaT细胞中的主要原碱基型人参皂苷中的一种。 当在UV-B照射之前对培养的角质形成细胞进行RB2,RB2显示对UV-B诱导的反应性氧物质升高和基质金属蛋白酶-2表达和分泌的抑制活性。 然而,使用浓度的RB2不能调节UV-B辐照的角质形成细胞中的细胞幸存者。 简而言之,RB2对UV-B照射下人角蛋白细胞细胞的拍摄具有保护作用。

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