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首页> 外文期刊>Cytokine >Influence of interleukin-2 and interferon-gamma in murine schistosomiasis.
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Influence of interleukin-2 and interferon-gamma in murine schistosomiasis.

机译：白细胞介素2和干扰素-γ对小鼠血吸虫病的影响。

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Schistosoma mansoni-infected mice were administered at the time of parasite residency in the lung with recombinant murine interleukin (IL)-2 or interferon-gamma (IFN-gamma), to evaluate the impact of cytokines in host responses to primary schistosomiasis. S. mansoni lung-stage schistosomula did not affect plasma lipids levels in BALB/c, while elicited significant (p<0.05) increase in free fatty acids (FA) and decrease in cholesterol plasma levels in C57BL/6 and CD1 mice, and stimulated expression of mRNA for Th2 cytokines in BALB/c and Th1 cytokines in C57BL/6 and CD1 mice. Production of specific antibodies was negligible in the 3 strains. Interleukin-2 treatment elicited significant (p<0.001) decrease in triglycerides (TG) in CD1, and decrease in TG and cholesterol plasma levels and down-regulation of TNF-alpha mRNA expression in C57BL/6 mice. Induction of type 2 cytokines and/or IFN-gamma mRNA expression did not lead to increase in percentage of specific antibody responders in any mouse strain. Exogenous IL-2-related reduction in cholesterol plasma levels and TNF-alpha mRNA expression in C57BL/6 mice was associated with significant (p<0.05) decrease in adult worm recovery and egg count. Treatment with IFN-gamma elicited significant (p<0.05) free FA plasma levels increase in BALB/c and C57BL/6 and decrease in CD1 mice. Expression of type 2 cytokines mRNA was stimulated in BALB/c and CD1 mice, yet was not accompanied with increase in humoral responses. Exogenous IFN-gamma-related reduction in free FA plasma levels and IFN-gamma mRNA response, and up-regulation of TNF-alpha mRNA expression in CD1 mice were associated with significant increase in adult worm burden and egg load. The data were discussed in an attempt to define host factors predictive of resistance to schistosome infection.
机译：在重组虫鼠白细胞介素（IL）-2或干扰素-γ（IFN-γ）寄生虫在肺中寄生虫感染时，对曼氏血吸虫感染的小鼠进行管理，以评估细胞因子对宿主对原发性血吸虫病反应的影响。曼氏沙门氏菌肺阶段血吸虫病不影响BALB / c中的血脂水平，而引起C57BL / 6和CD1小鼠的游离脂肪酸（FA）显着（p <0.05）升高和胆固醇血浆水平降低，并受到刺激C57BL / 6和CD1小鼠的BALB / c中Th2细胞因子和Th1细胞因子的mRNA表达。在3个菌株中特异性抗体的产生可以忽略不计。白介素2治疗引起CD1中的甘油三酸酯（TG）显着降低（p <0.001），C57BL / 6小鼠的TG和胆固醇血浆水平降低以及TNF-αmRNA表达下调。在任何小鼠品系中，诱导2型细胞因子和/或IFN-γmRNA表达均不会导致特异性抗体应答者百分比的增加。 C57BL / 6小鼠中胆固醇水平和TNF-αmRNA表达的外源性IL-2相关降低与成虫恢复和卵数显着降低（p <0.05）有关。 IFN-γ处理可引起BALB / c和C57BL / 6的游离FA血浆水平显着（p <0.05）升高，而CD1小鼠则降低。在BALB / c和CD1小鼠中刺激了2型细胞因子mRNA的表达，但并未伴随体液反应的增加。外源IFN-γ相关的游离FA血浆水平和IFN-γmRNA反应的降低以及CD1小鼠中TNF-αmRNA表达的上调与成虫蠕虫负担和卵负荷的显着增加有关。讨论数据是为了试图确定可预测对血吸虫感染抵抗力的宿主因素。

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