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首页> 外文期刊>Cytokine >Interleukin-1: a key inflammatory mediator in psoriasis?
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Interleukin-1: a key inflammatory mediator in psoriasis?

机译：白细胞介素-1：牛皮癣的关键炎症介质？

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The pro-inflammatory cytokine interleukin-1 (IL-1) is constitutively expressed by keratinocytes in vivo and has been shown to be expressed in psoriatic lesional skin. To determine what role the IL-1 system might contribute to the inflammatory process in psoriasis, semi-quantitative RT-PCR and cRNA microarray studies were performed on biopsies excised from lesional and non-lesional skin. Whilst IL-1alpha mRNA levels showed a reduction in lesional skin in a subset of patients, steady state IL-1beta mRNA was increased markedly. Neither of the two IL-1 receptor transcripts nor total IL-1 receptor antagonist exhibited major changes within the lesion. Expression of the IL-1-induced chemokine IL-8 was only observed in lesional epidermis. Functional genomic experiments comparing transcriptome profiles derived from psoriatic lesional skin and IL-1 stimulated keratinocytes demonstrated a striking level of overlap. Taken together, these data suggest that IL-1 is likely to be an important mediator in the initiation and maintenance of psoriatic plaques and may represent an attractive therapeutic target.
机译：促炎细胞因子白介素-1（IL-1）在体内由角质形成细胞组成性表达，并已显示在银屑病皮损皮肤中表达。为了确定IL-1系统可能在牛皮癣的炎症过程中起什么作用，对从病变和非病变皮肤切除的活检组织进行了半定量RT-PCR和cRNA微阵列研究。虽然IL-1alpha mRNA水平显示一部分患者的病变皮肤减少，但稳态IL-1beta mRNA却显着增加。两种IL-1受体转录物或总IL-1受体拮抗剂均未在病变内表现出重大变化。仅在病变表皮中观察到IL-1诱导的趋化因子IL-8的表达。功能性基因组实验比较了牛皮癣病灶皮肤和IL-1刺激的角质形成细胞的转录组谱，发现了惊人的重叠水平。综上所述，这些数据表明IL-1可能是银屑病斑块起始和维持中的重要介体，并且可能代表有吸引力的治疗靶标。

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