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Interlinking interleukin-7.

机译：互连白介素7。

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摘要

The signaling processes that maintain the homeostatic proliferation of peripheral T-cells and result in their self-renewal largely remain to be elucidated. Much focus has been placed on the anti-apoptotic function of the cytokine, interleukin-7 (IL-7), during T-cell development. But a more critical role has been ascribed to IL-7 as a mediator of peripheral T-cell maintenance. The biological effects responsive to IL-7 signaling are transduced through only a few well-known pathways. In this review we will focus on the signals transduced by IL-7 and similar cytokines, examining how proliferative signals originate from cytokine receptors, are amplified and eventually alter gene expression. In this regard we will highlight the crosstalk between pathways that promote survival, drive cell cycle progression and most importantly provide the needed energy to sustain these critical cellular activities. Though this review showcases much of what has been learned about IL-7 proliferative signaling, it also reveals the significant gaps in our knowledge about cytokine signaling in the very relevant context of peripheral T-cell homeostasis.
机译：维持外周T细胞的稳态增殖并导致其自我更新的信号传导过程仍有待阐明。在T细胞发育过程中，细胞因子白介素7（IL-7）的抗凋亡功能受到了广泛关注。但是，更重要的作用归因于IL-7作为外周T细胞维持的介质。仅通过一些众所周知的途径来转导对IL-7信号传导有响应的生物学效应。在这篇综述中，我们将重点关注由IL-7和类似细胞因子转导的信号，研究增殖信号如何源自细胞因子受体，被扩增并最终改变基因表达。在这方面，我们将重点介绍促进生存，驱动细胞周期进程并最重要的是提供维持这些关键细胞活动所需的能量的途径之间的串扰。尽管这篇综述展示了许多关于IL-7增殖信号传导的知识，但它也揭示了我们在外周T细胞动态平衡的非常相关的背景下对细胞因子信号传导的认识上的巨大差距。

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