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首页> 外文期刊>Cytokine >The PLPp-specific T-cell population promoted by pertussis toxin is characterized by high frequencies of IL-17-producing cells.
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The PLPp-specific T-cell population promoted by pertussis toxin is characterized by high frequencies of IL-17-producing cells.

机译：百日咳毒素促进的PLPp特异性T细胞群的特征是产生IL-17的细胞频率高。

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摘要

Experimental autoimmune encephalomyelitis (EAE) is commonly regarded as an animal model of the human disease multiple sclerosis (MS). Pertussis toxin (PTX) is routinely used for EAE induction in mice. Besides opening the blood-brain barrier, it acts as an adjuvant causing strong expansion of antigen-specific cells after coinjection with neuroantigens in IFA. Using an IL-17 ELISPOT assay we developed previously, we investigated the capability of PTX to induce proteolipid protein peptide 139-151(PLPp)-specific Th-17 cells in the immune periphery and in the thymus after coinjection with PLPp/IFA. PTX was found to induce peripheral PLPp-specific Th-17 cells in the draining lymph node and in the spleen, but not in the thymus. Our study indicates a new mechanism by which microbial agents can initiate or maintain autoimmune reactions and supports the growing role in particular for Th-17 cells in organ-specific autoimmune diseases like multiple sclerosis or EAE.
机译：实验性自身免疫性脑脊髓炎（EAE）通常被认为是人类疾病多发性硬化症（MS）的动物模型。百日咳毒素（PTX）通常用于小鼠的EAE诱导。除了打开血脑屏障外，它还可以作为佐剂，与IFA中的神经抗原共同注射后，引起抗原特异性细胞的强烈扩增。使用我们先前开发的IL-17 ELISPOT分析，我们研究了PTX在与PLPp / IFA共注射后在免疫周边和胸腺中诱导蛋白脂蛋白肽139-151（PLPp）特异性Th-17细胞的能力。发现PTX在引流淋巴结和脾脏中诱导外周PLPp特异性Th-17细胞，但在胸腺中却没有。我们的研究表明微生物制剂可以启动或维持自身免疫反应并支持尤其是Th-17细胞在器官特异性自身免疫疾病（如多发性硬化症或EAE）中的增长作用的新机制。

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