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首页> 外文期刊>Cytokine >Serum fetuin--a concentrations are inversely related to cytokine concentrations in patients with chronic renal failure.
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Serum fetuin--a concentrations are inversely related to cytokine concentrations in patients with chronic renal failure.

机译:血清胎球蛋白-与慢性肾功能衰竭患者的细胞因子浓度成反比。

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BACKGROUND/AIMS: A close relationship exists between inflammation and vascular calcification. Although fetuin-A is known to be an inhibitor of calcification, studies correlating levels of this glycoprotein to markers of inflammation are limited. To understand these relationships, we investigated the relationship between serum fetuin-A and proinflammatory cytokine levels in patients with chronic renal failure (CRF). METHODS: Thirty-two patients on haemodialysis (HD), 32 conservatively managed chronic kidney disease (CKD) patients and a control group of 25 subjects with normal renal function were enrolled in this study. Serum fetuin-A, IL-1beta, IL-6 and TNF-alpha levels were measured by ELISA. Correlations between serum fetuin-A and IL-1beta, IL-6 and TNF-alpha concentrations were investigated by the Spearman correlation test. RESULTS: In 64 CRF patients (on HD and with CKD), serum fetuin-A was significantly and inversely related to IL-1beta (P<0.001), IL-6 (P=0.025) and TNF-alpha levels (P=0.007), respectively. The serum fetuin-A levels of the control subjects were not significantly correlated to levels of the inflammatory markers IL-1beta, IL-6 and TNF-alpha (P=0.551, 0.985 and 0.984, respectively). CONCLUSION: The negative correlation between serum fetuin-A and cytokine concentrations in CRF patients supports the hypothesis of inflammation-dependent down-regulation of fetuin-A expression.
机译:背景/目的:炎症与血管钙化之间存在密切关系。尽管已知胎球蛋白A是钙化的抑制剂,但是将这种糖蛋白的水平与炎症标志物相关的研究仍然有限。为了理解这些关系,我们调查了慢性肾功能衰竭(CRF)患者血清胎球蛋白A与促炎细胞因子水平之间的关系。方法:本研究纳入了32例血液透析(HD)患者,32例保守治疗的慢性肾脏病(CKD)患者和25例肾功能正常的对照组。通过ELISA测量血清胎球蛋白-A,IL-1β,IL-6和TNF-α水平。通过Spearman相关检验研究了血清胎球蛋白A与IL-1β,IL-6和TNF-α浓度之间的相关性。结果:在64名CRF患者(HD和CKD患者)中,血清胎球蛋白A与IL-1β(P <0.001),IL-6(P = 0.025)和TNF-α水平显着且呈负相关(P = 0.007) ), 分别。对照受试者的血清胎球蛋白-A水平与炎症标志物IL-1β,IL-6和TNF-α的水平没有显着相关性(分别为P = 0.551、0.985和0.984)。结论:CRF患者血清胎球蛋白A与细胞因子浓度呈负相关,支持了炎症依赖性胎球蛋白A表达下调的假说。

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