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首页> 外文期刊>Cytokine >Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease.
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Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease.

机译：在老年痴呆症中血浆中APOE，可溶性CD40，CD40L和Abeta1-40水平的诊断效用。

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A continuous inflammatory state is associated with Alzheimer's disease (AD) evidenced by an increase in proinflammatory cytokines around beta-amyloid (Abeta) deposits. In addition, functional loss of CD40L is shown to result in diminished Amyloid precursor proton (APP) processing and microglial activation, supporting a prominent role of CD40-CD40L in AD etiology. We therefore hypothesize that a peripheral increase in Abeta may result in corresponding increase of sCD40 and sCD40L further contributing to AD pathogenesis. We measured plasma Abeta, sCD40 and sCD40L levels in 73 AD patients and compared to 102 controls matched on general demographics. We demonstrated that Abeta(1-40), levels of sCD40 and sCD40L are increased in AD and declining MMSE scores correlated with increasing sCD40L, which in turn, correlated positively with Abeta(1-42). We then combined sCD40, sCD40L, Abeta and APOE and found that this biomarker panel has high sensitivity and specificity (>90%) as a predictor of clinical AD diagnosis. Given the imminent availability of potentially disease modifying therapies for AD, a great need exists for peripheral diagnostic markers of AD. Thus, we present preliminary evidence for potential usefulness for combination of plasma sCD40, sCD40L along with Abeta(1-40) and APOE epsilon4 in improving the clinical diagnosis of AD.
机译：持续的炎症状态与阿尔茨海默氏病（AD）相关，这是由β-淀粉样蛋白（Abeta）沉积物周围促炎性细胞因子增加所证明的。此外，显示CD40L的功能丧失导致淀粉样前体质子（APP）加工和小胶质细胞活化减少，从而支持CD40-CD40L在AD病因中的重要作用。因此，我们假设Abeta的外围增加可能导致sCD40和sCD40L的相应增加，从而进一步促进AD发病。我们测量了73名AD患者的血浆Abeta，sCD40和sCD40L水平，并与一般人口统计学上匹配的102名对照进行了比较。我们证明，AD中的Abeta（1-40），sCD40和sCD40L的水平增加，而MMSE分数下降与sCD40L的增加相关，而sCD40L则与Abeta（1-42）呈正相关。然后，我们组合了sCD40，sCD40L，Abeta和APOE，发现该生物标志物组具有很高的敏感性和特异性（> 90％）作为临床AD诊断的预测指标。鉴于用于AD的潜在疾病修饰疗法的迫在眉睫的需求，对AD的外周诊断标记物存在极大的需求。因此，我们提供了血浆sCD40，sCD40L以及Abeta（1-40）和APOE epsilon4组合在改善AD临床诊断方面的潜在有用的初步证据。

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