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首页> 外文期刊>Cytokine >Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling.
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Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling.

机译:泛素化在模式识别受体和I型干扰素受体信号传导中的作用。

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摘要

Post-translational protein modifications are involved in all functions of living cells. This includes the ability of cells to recognize pathogens and regulate genes involved in their clearance, a concept known as innate immunity. While phosphorylation mechanisms play essential roles in regulating different aspects of the innate immune response, ubiquitination is now recognized as another post-translational modification that works in parallel with phosphorylation to orchestrate the final proper innate immune response against invading pathogens. More precisely, this review will discuss the most recent advances that address the role of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling.
机译:翻译后蛋白质修饰涉及活细胞的所有功能。这包括细胞识别病原体和调节参与其清除的基因的能力,这一概念被称为先天免疫。虽然磷酸化机制在调节先天免疫应答的不同方面起着至关重要的作用,但泛素化现已被认为是另一种翻译后修饰,与磷酸化同时起作用,以协调针对入侵病原体的最终适当先天免疫应答。更准确地说,本综述将讨论解决泛素化在模式识别受体和I型干扰素受体信号传导中作用的最新进展。

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