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首页> 外文期刊>Cytokine >Serum IL-18 levels in patients with type 1 diabetes: relations to metabolic control and microvascular complications.
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Serum IL-18 levels in patients with type 1 diabetes: relations to metabolic control and microvascular complications.

机译：1型糖尿病患者的血清IL-18水平：与代谢控制和微血管并发症的关系。

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The study was designed to examine serum IL-18 level and its relation to metabolic control parameters and microvascular complications in type 1 diabetes mellitus (DM). Sixty two patients with type 1 DM and 30 healthy individuals were enrolled in the study. Serum IL-18 levels of patients with type 1 DM were significantly increased compared to controls (293.4+/-133.4 vs 211.2+/-63.9 pg/ml, P=0.003). Patients with poor glycemic control had higher levels of IL-18 than patients with well glycemic control (329.9+/-141.0 vs 226.3+/-89.6 pg/ml, P=0.02). There was no significant difference between the serum IL-18 levels of patients with microvascular complications and those of patients without microvascular complications (307.6+/-127.6 vs 293.2+/-145.6 pg/ml, P>0.05). IL-18 correlated positively with HbA(1c) (r=0.32, P=0.01) and postprandial blood glucose (PPBG) (r=0.26, P=0.02); and negatively with HDL-cholesterol (HDL-C) (r=-0.38, P=0.007). By linear regression analysis, PPBG was determined as the most explanatory parameter for the alterations in serum IL-18 levels (P=0.02). High levels of IL-18 in patients with type 1 DM is related to short and long term glycemic control and HDL-C levels but not to microvascular complications.
机译：该研究旨在检查1型糖尿病（DM）的血清IL-18水平及其与代谢控制参数和微血管并发症的关系。本研究招募了62名1型DM患者和30名健康个体。与对照组相比，1型DM患者的血清IL-18水平显着升高（293.4 +/- 133.4与211.2 +/- 63.9 pg / ml，P = 0.003）。血糖控制不良的患者比血糖控制良好的患者具有更高的IL-18水平（329.9 +/- 141.0与226.3 +/- 89.6 pg / ml，P = 0.02）。有微血管并发症的患者和无微血管并发症的患者的血清IL-18水平之间没有显着差异（307.6 +/- 127.6 pg vs 293.2 +/- 145.6 pg / ml，P> 0.05）。 IL-18与HbA（1c）（r = 0.32，P = 0.01）和餐后血糖（PPBG）（r = 0.26，P = 0.02）呈正相关;而HDL-胆固醇（HDL-C）则为阴性（r = -0.38，P = 0.007）。通过线性回归分析，PPBG被确定为血清IL-18水平改变的最解释性参数（P = 0.02）。 1型DM患者中高水平的IL-18与短期和长期血糖控制和HDL-C水平有关，但与微血管并发症无关。

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