...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >The effect of repeated endurance exercise on IL-6 and sIL-6R and their relationship with sensations of fatigue at rest.
【24h】

The effect of repeated endurance exercise on IL-6 and sIL-6R and their relationship with sensations of fatigue at rest.

机译：反复的耐力运动对IL-6和sIL-6R的影响及其与休息时疲劳感的关系。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Strenuous, prolonged exercise increases interleukin-6 (IL-6) release. The effect of IL-6 is dependent on the availability of IL-6 receptors. Few studies have addressed the impact of exercise on IL-6 receptor levels or procalcitonin (PCT), an indicator of systemic inflammation. Changes in these molecules may give insight into cytokine-related mechanisms underlying exercise-related fatigue. Thirteen trained male subjects partook in the study. They cycled a total distance of 468 km over 6 days. Blood samples were obtained prior to and immediately following Day 1 of the study and then each morning prior to exercise. Blood samples were analysed for plasma IL-6, soluble IL-6 receptor (sIL-6R), C-reactive protein (CRP), PCT, creatine kinase (CK) and cortisol concentrations. Subjects also completed mood state questionnaires each day prior to exercise. IL-6 was elevated immediately post-exercise on Day 1 but was unchanged at rest for the duration of the event. In contrast, sIL-6R, CRP, PCT and CK concentrationswere unchanged immediately post-exercise on Day 1 but were significantly elevated at rest over the duration of the event compared with pre-event baseline. sIL-6R was highly correlated to CRP. Cortisol concentrations remained unchanged at all time points. In conclusion, strenuous, prolonged exercise stimulated an acute phase response which was maintained throughout the 6-day event. sIL-6R increase is associated with CRP and may affect subjective sensations of post-exercise fatigue at rest.
机译：长时间剧烈运动会增加白介素6（IL-6）的释放。 IL-6的作用取决于IL-6受体的可用性。很少有研究讨论运动对IL-6受体水平或降钙素原（PCT）（系统性炎症指标）的影响。这些分子的变化可能有助于深入了解运动相关疲劳背后的细胞因子相关机制。十三名受过训练的男性受试者参与了这项研究。他们在6天内骑行了468公里。在研究的第1天之前和之后以及之后每天早晨在运动之前获取血液样本。分析血样中的血浆IL-6，可溶性IL-6受体（sIL-6R），C反应蛋白（CRP），PCT，肌酸激酶（CK）和皮质醇浓度。受试者还每天在运动前填写情绪状态问卷。运动后第一天，IL-6立即升高，但在整个活动过程中静止时未改变。相反，运动后第1天sIL-6R，CRP，PCT和CK的浓度在运动后立即保持不变，但与事件前基线相比，在整个事件过程中静息时均显着升高。 sIL-6R与CRP高度相关。皮质醇浓度在所有时间点均保持不变。总之，剧烈，长时间的运动刺激了急性期反应，该反应在整个6天的活动中都得以维持。 sIL-6R升高与CRP有关，可能会影响运动后疲劳时的主观感觉。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号