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首页> 外文期刊>Cytokine >Day-to-day variation in plasma interleukin-6 concentrations in older adults.
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Day-to-day variation in plasma interleukin-6 concentrations in older adults.

机译：成年人血浆白细胞介素6浓度的每日变化。

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摘要

Interleukin-6 (IL-6) is a pro-inflammatory cytokine commonly used in studies as a means of assessing chronic inflammatory status. Despite the use of plasma IL-6 as a marker of chronic inflammation few studies exist that examine the variability of plasma IL-6 within and between individuals. The purpose of this study was to assess inter- and intra-variability of plasma IL-6 concentration in men and postmenopausal women. Sixteen healthy postmenopausal women and 5 men completed the 2-week study. Fasted venous blood samples were obtained on three consecutive mornings for two consecutive weeks (six blood draws per participant). Mean plasma IL-6 values were 2.00+/-1.74 pg/mL. Intra-variability was not significantly different (p>0.05) however inter-variability was significantly different (p<0.05). The index of individuality (II) was 0.20 and the standard error of the mean (SEM) was determined to equal 0.16 pg/mL (0.32 pg/mL; 1.96 SEM). An II of 0.20 demonstrates the need to carefully evaluate changes in plasma IL-6 concentration instead of utilizing population-based reference norms. In an older adult population until plasma IL-6 differences exceed 0.32 pg/mL such values could be considered normal fluctuation between trials and most likely not attributable to a nutrition intervention.
机译：白介素6（IL-6）是一种促炎细胞因子，通常在研究中用作评估慢性炎症状态的手段。尽管使用血浆IL-6作为慢性炎症的标志物，但是很少有研究检查个体内和个体之间血浆IL-6的变异性。这项研究的目的是评估男性和绝经后女性血浆IL-6浓度的内部和内部变异性。十六名健康的绝经后妇女和5名男性完成了为期2周的研究。在连续三个星期的连续两个星期的早晨中，获取禁食的静脉血样本（每个参与者抽六个血）。平均血浆IL-6值为2.00 +/- 1.74 pg / mL。内变异性差异不显着（p> 0.05），而变异性差异显着（p <0.05）。个性指数（II）为0.20，平均值的标准误差（SEM）确定为等于0.16 pg / mL（0.32 pg / mL; 1.96 SEM）。 II为0.20证明需要仔细评估血浆IL-6浓度的变化，而不是利用基于人群的参考标准。在老年人群中，直到血浆IL-6差异超过0.32 pg / mL为止，该值可以认为是试验之间的正常波动，并且很可能不是营养干预引起的。

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