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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Association of the eukaryotic vaginal virome with prophylactic antibiotic exposure and reproductive outcomes in a subfertile population undergoing in vitro fertilisation: a prospective exploratory study
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Association of the eukaryotic vaginal virome with prophylactic antibiotic exposure and reproductive outcomes in a subfertile population undergoing in vitro fertilisation: a prospective exploratory study

机译：在体外施肥中进行真核阴道生物与预防性抗生素暴露和生殖结果的关联，施肥群：探讨研究

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摘要

Objective The objective of this study was to use high‐throughput sequencing to describe the vaginal eukaryotic DNA virome in patients undergoing in vitro fertilisation (IVF) to examine associations between the vaginal virome, antibiotic exposure and IVF outcomes. Design Prospective exploratory study. Setting Single academic fertility centre. Population Subfertile women age 18–43?years undergoing their first IVF cycle with a fresh embryo transfer. Methods The primary exposure was prophylactic azithromycin or no azithromycin before IVF. A mid‐vaginal swab was obtained at the time of embryo transfer for virome analysis. Main outcome measures The primary outcomes compared between exposure groups were characteristics of vaginal virome and clinical pregnancy rates. Secondary outcomes were virome associations with number of oocytes retrieved, number of blastocysts and implantation rate. Results Twenty‐six women contributed a vaginal swab before embryo transfer. There were no significant differences in IVF outcomes between azithromycin groups. There was no association between viral diversity and clinical pregnancy overall. A higher diversity of herpesviruses and α‐papillomaviruses was observed in samples from the azithromycin‐treated group compared with the no azithromycin group ( P ?=?0.04). In women that received azithromycin, viral diversity was higher in the group that did not achieve clinical pregnancy compared with those who did ( P ?=?0.06). Conclusions We demonstrate that the vaginal eukaryotic virome in women undergoing IVF is associated with antibiotic exposure. Additionally, we demonstrate an inverse trend between viral diversity and pregnancy, with a higher number of viruses detected associated with failure to achieve clinical pregnancy in the azithromycin group. Tweetable abstract Higher viral diversity is associated with prophylactic antibiotic exposure in subfertile women undergoing IVF.
机译：目的本研究的目的是使用高通量测序来描述在体外施肥（IVF）的患者中描述阴道真核DNA病毒体，以检查阴道生物，抗生素暴露和IVF结果之间的关联。设计前瞻性探索研究。设置单学术生育中心。人口患者年龄18-43岁以下的妇女在新的胚胎转移中接受了第一个IVF周期。方法初级曝光是预防性二十霉素或IVF前的氮霉素。在胚胎转移时获得中阴道拭子进行病毒体分析。主要结果测量接触基团之间比较的主要结果是阴道病毒和临床妊娠率的特征。二次结果是病毒组合，其卵母细胞数量检索，胚泡和植入率的数量。结果二十六名女性在胚胎转移之前贡献了阴道拭子。阿奇霉素组之间的IVF结果没有显着差异。病毒多样性与整体临床怀孕之间没有关联。与NO氮霉素组（P≤X.04）相比，在阿奇霉素治疗组的样品中观察到较高的疱疹病毒和α-乳头瘤病毒。在接受阿奇霉素的女性中，与那些（p？= 0.06）相比，在没有达到临床怀孕的组中，病毒多样性较高。结论我们证明，接受IVF的女性中的阴道真核生物与抗生素暴露有关。此外，我们展示了病毒多样性和妊娠之间的逆趋势，患有较高数量的病毒，检测到与氮霉素组中的临床妊娠相关联。 Twelable摘要较高的病毒多样性与接受IVF的骨骼女性的预防性抗生素暴露有关。

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    Eskew AM; Stout MJ; Bedrick BS; Riley JK; Omurtag KR; Jimenez PT; Odem RR; Ratts VS; Keller SL; Jungheim ES; Wylie KM;

  • 作者单位

    Department of Obstetrics and GynecologyWashington University in St LouisSt Louis MO USA;

    Department of Obstetrics and GynecologyWashington University in St LouisSt Louis MO USA;

    Department of Obstetrics and GynecologyWashington University in St LouisSt Louis MO USA;

    Department of Obstetrics and GynecologyWashington University in St LouisSt Louis MO USA;

    Department of Obstetrics and GynecologyWashington University in St LouisSt Louis MO USA;

    Department of Obstetrics and GynecologyWashington University in St LouisSt Louis MO USA;

    Department of Obstetrics and GynecologyWashington University in St LouisSt Louis MO USA;

    Department of Obstetrics and GynecologyWashington University in St LouisSt Louis MO USA;

    Department of Obstetrics and GynecologyWashington University in St LouisSt Louis MO USA;

    Department of Obstetrics and GynecologyWashington University in St LouisSt Louis MO USA;

    Department of PediatricsWashington University in St LouisSt Louis MO USA;

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  • 正文语种 eng
  • 中图分类 妇产科学;
  • 关键词

    Embryo transfer; in vitro fertilisation; reproductive tract microbiome; vaginal virus; virome;

    机译：胚胎转移;体外施肥;生殖道微生物组;阴道病毒;生气;

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