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首页> 外文期刊>Cytokine >Age-dependent endothelial progenitor cell mobilization and cardiac surgery.
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Age-dependent endothelial progenitor cell mobilization and cardiac surgery.

机译：年龄依赖性内皮祖细胞动员和心脏手术。

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摘要

We read with a great interest the letter by Dr. Y. Denizot and N. Nathan commenting on our recently published paper (Ref. [1]), suggesting the soluble Flt-1 is capable of sequestering ligand and preventing signal transduction. As pointed by Dr. Y. Denizot and N. Nathan, sFlt-1 is released during CPB; plasma sFlt-1 is related to the occurrence of post-operative complications [2], Studies have reported that Flt-1 expression and signaling decreased with age [3,4]. It is thus tempting to speculate that CPB-induced sFlt-1 release might be different in infants and young children compared to older individuals. Investigation of plasma sFlt-1 levels during CPB in infants and young children might be of interest to test this hypothesis.
机译：我们非常感兴趣地阅读了Y. Denizot和N. Nathan博士在我们最近发表的论文（参考文献[1]）上的评论，这封信暗示可溶性Flt-1能够螯合配体并阻止信号转导。正如Y. Denizot博士和N. Nathan博士所指出的，sFlt-1在CPB期间被释放。血浆sFlt-1与术后并发症的发生有关[2]，有研究报道Flt-1的表达和信号随年龄而降低[3,4]。因此，很容易推测与婴儿相比，婴儿和幼儿中CPB诱导的sFlt-1释放可能有所不同。可能需要对婴儿和幼儿CPB期间血浆sFlt-1水平的研究进行验证。

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