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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Lower risk of invasive meningococcal disease during pregnancy: national prospective surveillance in England, 2011-2014
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Lower risk of invasive meningococcal disease during pregnancy: national prospective surveillance in England, 2011-2014

机译：怀孕期间侵入性脑膜炎疾病病症的风险降低：英格兰的全国预期监视，2011-2014

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Objective To describe cases of invasive meningococcal disease (IMD) in women of childbearing age and to estimate the disease incidence and relative risk of IMD in pregnant compared with non-pregnant women. Design Prospective enhanced national surveillance for IMD. Setting England. Population Women of reproductive age (15-44 years) with laboratory-confirmed IMD. Methods Public Health England conducts enhanced national surveillance for IMD in England. Laboratory-confirmed cases are followed up with postal questionnaires to general practitioners. All cases confirmed in women of reproductive age from 1 January 2011 to 31 December 2014 were included. Main outcome measures Annual IMD incidence and relative risk of IMD in pregnant compared with non-pregnant women of reproductive age. Results During the 4-year surveillance period, there were 1502 cases of IMD in females across England; of these, 310 (20.6%) cases were in women of reproductive age, including four women who were pregnant at the time of IMD confirmation (1.3%). Serogroup distribution of IMD cases in women of childbearing age was similar to the overall distribution. The four cases in otherwise healthy pregnant women were confirmed across all trimesters and all survived; one case in the first trimester had a septic miscarriage. The incidence of IMD was lower in pregnant than in non-pregnant women (0.16 compared with 0.76 per 100 000 pregnant and non-pregnant years, respectively), giving a lower risk of IMD in pregnant women (incidence rate ratio, IRR, 0.21; 95% confidence interval, 0.06-0.54). Conclusions Pregnant women are nearly five times less likely to develop IMD compared with non-pregnant women, but the infection can be severe. Tweetable abstract The risk of meningococcal disease is lower in pregnant women compared with non-pregnant women; the infection can occur across all trimesters and can be severe.
机译：目的描述生育年龄妇女侵袭性脑膜炎疾病（IMD）的病例，与非孕妇对怀孕IMD的疾病发病率及相对风险。设计前瞻增强了IMD的国家监督。设置英格兰。生殖年龄人口妇女（15-44岁）与实验室证实的IMD。方法公共卫生英国对英格兰的IMD进行了增强的国家监察。实验室确认的案件随访邮政问卷向全科医生。包括2011年1月1日至2014年12月31日的生殖年龄妇女证实的所有案件。与非孕妇生殖年龄的非孕妇相比，主要结果衡量年度IMD发病率和IMD的相对风险。结果在4年监督期间，英格兰的女性中有1502例IMD;其中310例（20.6％）病例是生殖年龄的妇女，其中4名在IMD确认时怀孕的妇女（1.3％）。育龄妇女育龄妇女IMD病例的血清组分布类似于整体分布。在所有修整者身上确认了另外健康的孕妇的四个案例，都幸存下来;在前三个月的一个案例有一种化粪池的流产。 IMD的发生率低于非孕妇（0.16，分别为每100 000人的0.76，分别为0.76，孕妇IMD的风险较低（发病率比，0.21; 95％置信区间，0.06-0.54）。结论孕妇与非孕妇相比，孕妇的可能性近5倍，但感染可能是严重的。 Temetable摘要与非孕妇相比，孕妇脑膜炎球菌病的风险较低;感染可能会发生在所有修整器中，并且可能是严重的。

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