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首页> 外文期刊>Cytokine >Cytokines profile in serum of homozygous familial hypercholesterolemia is changed by LDL-apheresis.
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Cytokines profile in serum of homozygous familial hypercholesterolemia is changed by LDL-apheresis.

机译：LDL置换改变纯合子家族性高胆固醇血症血清中的细胞因子谱。

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OBJECTIVE: The effects of LDL-apheresis (LDLa) with dextran sulphate on plasma cytokines in 6 homozygous familial hypercholesterolemic (HozFH) patients, were evaluated. METHODS: Plasma IL-1alpha; IL-1ra; IL-4; IL-6; IL-10; IL-12(p40); IL-12(p70); TNF-alpha, sTNF-R, VEGF, VEGF-R1, E-Selectin (ESEL), and P-Selectin (PSEL) concentrations were measured before and after LDLa on three consecutive sessions for each patient. RESULTS: TNF-alpha was significantly reduced (-60%; P=0.01), while TNF-R was only slightly increased (+15%), although not significantly. Plasma VEGF was significantly reduced (-57%; P=1.87301E-05), while VEGF-R1 was significantly increased (+56%; P=0.05). ESEL and PSEL were reduced but not to a statistically significant extent (-19%, -15%, respectively). IL-1alpha level was dramatically reduced (-87%; P=0.0001). IL-1ra concentration was only slightly increased in plasma, but not significantly. IL-4 and IL-10 levels were significantly reduced in plasma after apheresis (-50%; P=0.03, and -55%; P=0.004, respectively). On the contrary, IL-6 concentration showed a slight decrease (-8%). Plasma IL-12p40 was significantly increased (+47%; P=0.0004). On the other hand, IL-12p70 was reduced, but the difference (-31%) was not statistically significant. CONCLUSIONS: Plasma cytokines imbalance is associated with inflammation and atherogenesis. In this study LDLa changed several circulating cytokines inducing anti-inflammatory and anti-atherogenic changes in cytokines plasma profile in HozFH patients with/without pre-existing angiographically demonstrated coronary heart disease (CHD) and aortic valvular disease (AVD).
机译：目的：评估硫酸葡聚糖对低密度脂蛋白（LDL）的溶解对6名纯合子家族性高胆固醇血症（HozFH）患者血浆细胞因子的影响。方法：血浆IL-1alpha; IL-1ra; IL-4; IL-6; IL-10; IL-12（p40）; IL-12（p70）;在每位患者连续三个疗程的LDLa前后，分别测量TNF-α，sTNF-R，VEGF，VEGF-R1，E-选择素（ESEL）和P-选择素（PSEL）的浓度。结果：TNF-α显着降低（-60％; P = 0.01），而TNF-R仅略微升高（+ 15％），尽管不显着。血浆VEGF显着降低（-57％; P = 1.87301E-05），而VEGF-R1显着升高（+ 56％; P = 0.05）。 ESEL和PSEL降低了，但没有统计学上的显着性降低（分别为-19％，-15％）。 IL-1α水平显着降低（-87％; P = 0.0001）。 IL-1ra浓度在血浆中仅略有增加，但没有明显增加。血液分离后血浆中的IL-4和IL-10水平显着降低（分别为-50％; P = 0.03和-55％; P = 0.004）。相反，IL-6浓度略有下降（-8％）。血浆IL-12p40显着升高（+ 47％; P = 0.0004）。另一方面，IL-12p70降低，但差异（-31％）在统计学上不显着。结论：血浆细胞因子失衡与炎症和动脉粥样硬化有关。在这项研究中，LDLa改变了HozFH患者中有/没有预先存在血管造影证实的冠心病（CHD）和主动脉瓣膜病（AVD）的几种循环细胞因子，从而诱导细胞因子血浆分布的抗炎和抗动脉粥样硬化变化。

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