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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >First trimester screening for pre‐eclampsia in Chinese pregnancies: case–control study
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First trimester screening for pre‐eclampsia in Chinese pregnancies: case–control study

机译：中国怀孕前葛兰普查前妊娠早期筛查：病例对照研究

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摘要

Objective To assess the potential of screening for pre‐eclampsia (PE) in a Chinese population. Design Case–control study. Setting Teaching hospital in Hong Kong. Population A total of 3330 women having a viable singleton pregnancy attending first‐trimester Down‐syndrome screening. Methods Mean arterial pressure (MAP), bilateral uterine artery pulsatility index (UtA‐PI), and placental growth factor (PlGF) were measured. Screening markers were transformed to multiples of the gestational median (MoM) and adjusted for maternal and pregnancy characteristics. MoM distributions in PE and non‐PE pregnancies were compared with published expected values. PE screening performance was assessed using area under receiver operating curves (AUROC). Main outcome measures PE detection rate. Results A total of 30 (0.9%) women developed either early (34?weeks) or late (≥34?weeks) onset PE. MAP was dependent on maternal BMI, UtA‐PI on fetal crown rump length, uterine artery peak systolic velocity (UtA‐PSV) on maternal age and gestation, and PlGF on gestation in non‐PE pregnancies. MoM distributions determined using published Fetal Medicine Foundation models deviated significantly from one for both MAP ( P?? 0.0001) and PI ( P?? 0.0001), but not PlGF ( P?=? 0.52) in non‐PE pregnancies, whilst PlGF MoM distributions in those who developed early as opposed to late onset PE were significantly higher ( P?=? 0.05). AUROC for any PE using multiple markers was 0.72 (95% CI: 0.64–0.81) with detection rates of 72 and 55% for early and late PE, respectively, for a 10% false positive rate. Conclusion Detection rates for PE in our Chinese population were lower than the expected 90–95% even after adjusting MoM for local women's characteristics. Funding General Research Fund (Project number 470513). Tweetable abstract Pre‐eclampsia screening in the Chinese population had detection rates lower than previously published results.
机译：目的探讨中国人口前葛兰普查（PE）筛查的潜力。设计案例控制研究。在香港设定教学医院。人口共有3330名妇女有一个可行的单身妊娠，参加妊娠晚期唐氏综合症筛查。方法测定平均动脉压（MAP），双侧子宫动脉脉动性指数（UTA-PI）和胎盘生长因子（PLGF）。将筛选标记物转化为妊娠中值（MOM）的倍数，并调整母体和妊娠特征。将PE和非体育妊娠的妈妈分布与公布的预期值进行比较。使用接收器操作曲线（AUROC）下的区域评估PE筛选性能。主要观点测量PE检测率。结果共有30（0.9％）妇女早期（＆ 34个？周）或晚期（≥34？周）发作。地图依赖于胎儿冠臀长度的母体BMI，UTA-PI对孕产妇年龄和妊娠的子宫动脉峰值收缩速度（UTA-PSV），以及在非体育妊娠中妊娠的PLGF。使用公开的胎儿药物基础模型测定的母亲分布显着偏离了两个用于两个地图（P？<0.0001）和PI（p≤0.0001），但在非体育妊娠中不是PLGF（p？= 0.52） ，虽然PLGF妈妈在早期开发的那些那些与晚期开始PE的那些妈妈的分布显着升高（P？=？<0.05）。使用多个标记物的任何PE的Auroc分别为0.72（95％CI：0.64-0.81），分别具有72和55％的检测率，分别为10％假阳性率。结论中国人群体育率检测率低于预期的90-95％，即使在调整妈妈的地方妇女的特征。资助一般研究基金（项目编号470513）。在中国人口中发布的摘要摘要预先普利坦斯筛查比以前公布的结果低。

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