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首页> 外文期刊>Cytokine >Inflammation-related proteins in the blood of extremely low gestational age newborns. The contribution of inflammation to the appearance of developmental regulation.
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Inflammation-related proteins in the blood of extremely low gestational age newborns. The contribution of inflammation to the appearance of developmental regulation.

机译：极低胎龄新生儿血液中的炎症相关蛋白。炎症对发育调节的出现的贡献。

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BACKGROUND: We wanted to assess to what extent concentrations of circulating proteins appear to be developmentally regulated, and to what extent such regulation is influenced by intra-uterine inflammation. METHODS: We measured 22 proteins in blood obtained on postnatal days 1, 7, and 14 from 818 children born before the 28th week of gestation for whom we also had information about placenta morphology. RESULTS: Within the narrow gestational age range of this sample, some protein concentrations increase in blood with increasing gestational age. More commonly, the concentrations of inflammation-related proteins decrease with increasing gestational age. We observed this inverse pattern both in children whose placenta was and was not inflamed. CONCLUSIONS/INFERENCES: Regardless of whether or not the placenta is inflamed, the concentrations of inflammation-related proteins in early blood specimens appear to be developmentally regulated with the most common pattern being a decrease with increasing gestational age.
机译：背景：我们想评估循环蛋白的浓度在多大程度上受到发育调节，以及这种调节受子宫内炎症影响的程度。方法：我们测量了在出生后第1、7和14天从妊娠28周之前出生的818名儿童的血液中获得的22种蛋白质，我们还获得了有关胎盘形态的信息。结果：在该样品的狭窄胎龄范围内，血液中的某些蛋白质浓度随胎龄的增加而增加。更常见的是，炎症相关蛋白的浓度随着胎龄的增加而降低。我们在胎盘发炎和未发炎的儿童中都观察​​到了这种相反的模式。结论/结论：不论胎盘是否发炎，早期血液标本中炎症相关蛋白的浓度似乎都受到发育调节，最常见的模式是随着胎龄的增加而降低。

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