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首页> 外文期刊>Cytokine >Long-term overexpression of human granulocyte colony-stimulating factor in transgenic mice: persistent neutrophilia with no increased mortality for more than one year.
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Long-term overexpression of human granulocyte colony-stimulating factor in transgenic mice: persistent neutrophilia with no increased mortality for more than one year.

机译：人类粒细胞集落刺激因子在转基因小鼠中的长期过度表达：持续中性粒细胞增多，死亡率没有超过一年的增加。

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摘要

To investigate possible adverse consequences of persistent neutrophil overproduction, mice transgenic for human granulocyte colony-stimulating factor (hG-CSF) were studied for more than 1 year. They showed marked granulocytopoiesis and neutrophilia. Continuous medullary and extramedullary granulocytopoiesis resulted in marked changes in bone and liver. In the liver, haemorrhage and focal necrosis and a few haemangiosarcomas were present, presumably caused by the destructive granulocytopoiesis. Despite the high incidence of lung infiltration by mature neutrophils, lung lesions rarely appeared. Although there was a persistent increase in neutrophils, mortality of the mice did not differ from that of non-transgenic littermates at least within 1 year after birth. Factors other than overproduction of G-CSF and extensive neutrophilia could be required for the development of neutrophil-mediated acute and chronic tissue damage. Copyright 2000 Academic Press.
机译：为了研究持续中性粒细胞过度生产的可能不利后果，研究了人类粒细胞集落刺激因子（hG-CSF）转基因小鼠超过1年。他们表现出明显的粒细胞生成和中性粒细胞增多。连续的髓样和髓外的粒细胞生成导致骨骼和肝脏的明显变化。在肝脏中，存在出血和局灶性坏死以及少量血管肉瘤，可能是由破坏性粒细胞生成所致。尽管成熟的中性粒细胞肺浸润发生率很高，但很少出现肺部病变。尽管嗜中性粒细胞持续增加，但至少在出生后一年内小鼠的死亡率与非转基因同窝仔的死亡率没有差异。除了中性粒细胞生成过多和广泛的嗜中性粒细胞增多以外，其他因素也可能是嗜中性粒细胞介导的急性和慢性组织损伤发展的原因。版权所有2000学术出版社。

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