Transforming growth factor beta1 blocks the release of collagen fragments from boving nasal cartilage stimulated by oncostatin M in combination with IL-1alpha.

Hui W; Rowan AD; Cawston T

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Transforming growth factor beta1 blocks the release of collagen fragments from boving nasal cartilage stimulated by oncostatin M in combination with IL-1alpha.

机译：转化生长因子beta1阻止由制瘤素M结合IL-1alpha刺激的鼻软骨释放胶原蛋白片段。

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Oncostatin M in combination with interleukin-1 (IL-1) induced a rapid and reproducible release of collagen from bovine nasal cartilage in culture. This release was accompanied by a high collagenolytic activity and low or absent tissue inhibitor of metalloproteinase-1 activity in the culture medium. Transforming growth factor-beta1 was able to block this release of collagen from the tissue, and reduce the expression and secretion of collagenases whilst maintaining TIMP-1 levels from bovine nasal chondrocytes. This study shows for the first time that TGF-beta1 can protect cartilage collagen from destruction. Copyright 2000 Academic Press.

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《Cytokine》 |2000年第6期|共5页
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Hui W; Rowan AD; Cawston T;
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正文语种 eng
中图分类细胞生物学;
关键词
Collagen; Collagenases; Interleukin-1; Interstitial Collagenase genetics; 胶原; 胶原酶类; 白细胞介素1; 鼻中隔; 肽类; 金属蛋白酶1组织抑制剂; 转化生长因子β;

机译：Collagen;Collagenases;Interleukin-1;Interstitial Collagenase genetics;胶原;胶原酶类;白细胞介素1;鼻中隔;肽类;金属蛋白酶1组织抑制剂;转化生长因子β;

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专利

1. Transforming growth factor beta1 blocks the release of collagen fragments from boving nasal cartilage stimulated by oncostatin M in combination with IL-1alpha. [J] . Hui W, Rowan AD, Cawston T Cytokine . 2000,第6期

机译：转化生长因子beta1阻止由制瘤素M结合IL-1alpha刺激的鼻软骨释放胶原蛋白片段。
2. Sodium valproate blocks the transforming growth factor (TGF)-beta1 autocrine loop and attenuates the TGF-beta1-induced collagen synthesis in a human hepatic stellate cell line. [J] . Watanabe T, Tajima H, Hironori H, International journal of molecular medicine . 2011,第6期

机译：丙戊酸钠阻断人肝星状细胞系中的转化生长因子（TGF）-β1自分泌环并减弱TGF-β1诱导的胶原蛋白合成。
3. Transforming growth factor beta1 and additional renoprotective effect of combination ACE inhibitor and angiotensin II receptor blocker in hypertensive subjects with minor renal abnormalities: a 24-week randomized controlled trial. [J] . Scaglione R, Argano C, Corrao S, Journal of hypertension . 2005,第3期

机译：在患有轻度肾脏异常的高血压受试者中，转化生长因子beta1以及ACE抑制剂和血管紧张素II受体阻滞剂联合使用的其他肾保护作用：一项24周的随机对照试验。
4. Concentration Determination of Collagen and Proteoglycan in Bovine Nasal Cartilage by Fourier Transform Infrared Imaging and PLS [C] . Zhang Xue-Xi, Xiao Zhi-Yan, Yin Jian-Hua, International conference on photonics and imaging in biology and medicine . 2014

机译：傅立叶变换红外成像和PLS法测定牛鼻软骨中胶原和蛋白聚糖的含量。
5. The dentate gyrus of the hippocampus: roles of transforming growth factor beta1 (TGFbeta1) and adult neurogenesis in the expression of spatial memory. [D] . Martinez Canabal, Alonso. 2013

机译：海马齿状回：转化生长因子β1（TGFbeta1）和成人神经发生在空间记忆表达中的作用。
6. Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1 -3 -8 and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α [O] . W Hui, A Rowan, T Cawston 2001

机译：胰岛素样生长因子1阻断胶原蛋白的释放并下调抑癌素M联合白介素1α刺激牛鼻软骨中基质金属蛋白酶-1-3-8和-13 mRNA的表达
7. Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α [O] . Hui, W, Rowan, A, Cawston, T 2001

机译：胰岛素样生长因子1阻断胶原释放并下调抑癌素M与白介素1α联合刺激牛鼻软骨中基质金属蛋白酶-1，-3，-8和-13 mRNA的表达

Transforming growth factor beta1 blocks the release of collagen fragments from boving nasal cartilage stimulated by oncostatin M in combination with IL-1alpha.

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