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首页> 外文期刊>Cytokine >Changes of cytokines during the course of graft-versus-host disease following bone marrow transplantation: a case report.
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Changes of cytokines during the course of graft-versus-host disease following bone marrow transplantation: a case report.

机译：骨髓移植后移植物抗宿主病过程中细胞因子的变化：一例报告。

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Allogeneic bone marrow transplantation was performed in a 24-year-old woman with acute myelogenous leukemia in the first remission (FAB classification: M4). Graft-versus-host disease occurred from around day 150 after bone marrow transplantation. The levels of tumour necrosis factor-alpha, interleukin 12, and intercellular adhesion molecule-1 were elevated in the early stage of graft-versus-host disease, followed by elevation of interleukin 10 and interleukin 8. Her symptoms subsequently improved and all of these parameters became normal. The levels of thrombomodulin and plasminogen activator inhibitor type 1 showed changes that were in parallel with the clinical course. Interleukin 1beta, interleukin 6, interleukin 2, and interferon-gamma showed no changes throughout the course of her graft-versus-host disease. These findings suggested the possibility that release of inflammatory molecules occurred at the onset of graft-versus-host disease and caused vascular endothelial damage, which led to the exacerbation of her disease. Copyright 2000 Academic Press.
机译：首次缓解时，对一名患有急性髓性白血病的24岁女性进行了异体骨髓移植（FAB分类：M4）。移植物抗宿主病发生于骨髓移植后约150天。在移植物抗宿主病的早期阶段，肿瘤坏死因子-α，白介素12和细胞间粘附分子-1的水平升高，随后白介素10和白介素8升高。她的症状随后得到改善，所有这些参数变得正常。 1型血栓调节蛋白和纤溶酶原激活物抑制剂的水平显示出与临床过程平行的变化。白细胞介素1β，白细胞介素6，白介素2和干扰素-γ在她的移植物抗宿主病的整个过程中均未显示变化。这些发现表明，炎症分子的释放可能发生在移植物抗宿主病的发作并引起血管内皮损伤，从而加剧了她的疾病。版权所有2000学术出版社。

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