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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Conservative management of women with cervical intraepithelial neoplasia grade 2 in Denmark: a cohort study
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Conservative management of women with cervical intraepithelial neoplasia grade 2 in Denmark: a cohort study

机译：丹麦宫颈上皮内肿瘤患者妇女保守管理：队列研究

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Objective Assess the progression, persistence, and regression of cervical intraepithelial neoplasia grade 2 (CIN2) after new guidelines on conservative treatment, compared with previous practice. Design Nationwide register‐based cohort study. Setting Denmark. Population Women aged 18–44?years diagnosed with CIN2 on biopsy: 6721 in 2008–2011 and 6399 in 2014–2017. Methods Register data were retrieved from before (2008–2011) and after (2014–2017) the introduction of new guidelines. Histology diagnoses at second visit were used to assess progression (CIN3+), persistence (CIN2), or regression (CIN1/normal). Main outcome measures Proportion of CIN2 by type of management. Relative risk (RR) and corresponding 95% confidence intervals (95%?CIs) for progression, persistence, and regression at second visit in 2014–2017, versus 2008–2011. Results The proportion of CIN2 managed conservatively increased from 29.6% in 2008–2011 to 53.3% in 2014–2017 (RR 1.81, 95%?CI 1.73–1.89). Time to second visit increased by 2?months. Regression increased from 23.5 to 30.2% (RR 1.29, 95%?CI 1.22–1.36), whereas persistence and progression decreased, from 42.6 to 34.9% (RR 0.82, 95%?CI 0.78–0.86) and from 28.0 to 22.8% (RR 0.81, 95%?CI 0.77–0.86), respectively. In 2008–2011, women managed conservatively had a regression rate of 41.8%, persistence rate of 40.9%, and progression rate of 16.6%. In 2014–2017, these rates were 46.7, 35.5, and 17.1%, respectively. Conclusion After implementation of the new guidelines, conservative management became more frequent, and is now used for more than half of women with CIN2. Lesion regression became more frequent, now experienced by 47% of women managed conservatively. Similar regression rates were seen in women younger and older than 30?years, suggesting that conservative management is justifiable for women of childbearing age. Tweetable abstract In Denmark, more than half of women with CIN2 are managed conservatively, and half of these women experience lesion regression.
机译：目的评估在保守治疗的新准则后宫颈上皮内瘤级2（CIN2）的进展，持续性和回归，与以前的做法相比。基于寄存器的队列队列研究。设置丹麦。 18-44岁的人口妇女患者诊断为CIN2患有CIN2，2008 - 2011年2008 - 2011年和2014-2017年的6721年。方法从之前（2008-2011）和（2014-2017）之前检索寄存器数据，并在推出新的准则之后。第二次访问中的组织学诊断用于评估进展（CIN3 +），持久性（CIN2）或回归（CIN1 / NORMAT）。主要结果按管理类型测量CIN2的比例。相对风险（RR）和相应的95％置信区间（95％？CIS）2014 - 2017年第二次访问的进展，持续性和回归，而2008 - 2011年。结果2014 - 2011年CIN2管理的比例从2008 - 2011年的29.6％增加到53.3％（RR 1.81,95％？CI 1.73-1.89）。第二次访问的时间增加了2个月。回归从23.5增加到30.2％（RR 1.29,95％？CI 1.22-1.36），而持久性和进展降低，从42.6降至3​​4.9％（RR 0.82,95％？CI 0.78-0.86）和28.0至22.8％（ RR 0.81,95％？CI 0.77-0.86）。 2008 - 2011年，女性保守地管理的回归率为41.8％，持续率为40.9％，进展率为16.6％。 2014 - 2017年，这些利率分别为46.7,35.5和17.1％。结论实施新的准则后，保守管理变得更加频繁，现在使用了超过一半的女性CIN2。 Lesion回归变得更加频繁，现在有47％的女性保守管理。在女性年轻人和30岁以上的女性和年龄超过30年的类似回归率，这表明保守管理对育龄妇女来说是合理的。丹麦的Twelable摘要，超过一半的CIN2女性保守管理，其中一半的女性经历了病变回归。

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