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首页> 外文期刊>Cytokine >alpha-Cyclodextrin enhances myoblast fusion and muscle differentiation by the release of IL-4.
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alpha-Cyclodextrin enhances myoblast fusion and muscle differentiation by the release of IL-4.

机译：α-环糊精通过释放IL-4增强成肌细胞融合和肌肉分化。

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摘要

Muscle fibers are formed during embryonic development by the fusion of mononucleated myoblasts. The spatial structure and molecular composition of the sarcolemma are crucial for the myoblast recognition and fusion steps. Cyclodextrins are a group of substances that have the ability to solubilize lipids through the formation of molecular inclusion complexes. Previously, we have shown that methyl-beta-cyclodextrin (MbCD) enhances muscle differentiation. Here, we analyzed the effects of alpha-cyclodextrin (aCD) during myogenesis. Myogenic cultures treated with aCD showed an increase in myoblast fusion and in the expression of myogenin, sarcomeric tropomyosin and desmin. aCD-conditioned media accelerates myogenesis in a similar way as aCD does, and increased levels of IL-4 were found in aCD-conditioned media. aCD-induced effects on myogenesis were inhibited by an anti-IL4 antibody. These results show that alpha-cyclodextrin induces myogenic differentiation by the release of IL-4.
机译：肌纤维是在胚胎发育过程中通过单核成肌细胞融合形成的。肌膜的空间结构和分子组成对于成肌细胞的识别和融合步骤至关重要。环糊精是一组具有通过形成分子包合配合物来溶解脂质的能力的物质。以前，我们已经表明，甲基-β-环糊精（MbCD）增强肌肉分化。在这里，我们分析了α-环糊精（aCD）在肌发生过程中的作用。用aCD处理的肌原性培养物显示成肌细胞融合以及肌原蛋白，肌节肌原肌球蛋白和结蛋白的表达增加。 aCD条件培养基与aCD相似，可促进肌发生，在aCD条件培养基中发现IL-4水平升高。抗IL4抗体抑制了aCD诱导的对肌发生的作用。这些结果表明，α-环糊精通过IL-4的释放诱导肌原性分化。

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