• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BJU international >Pretreatment with low-energy shock waves induces renal vasoconstriction during standard shock wave lithotripsy (SWL): a treatment protocol known to reduce SWL-induced renal injury.
【24h】

Pretreatment with low-energy shock waves induces renal vasoconstriction during standard shock wave lithotripsy (SWL): a treatment protocol known to reduce SWL-induced renal injury.

机译：具有低能冲击波的预处理在标准冲击波裂解（SWL）期间诱导肾血管收缩：已知的治疗方案，以降低SWL诱导的肾损伤。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To test the hypothesis that the pretreatment of the kidney with low-energy shock waves (SWs) will induce renal vasoconstriction sooner than a standard clinical dose of high-energy SWs, thus providing a potential mechanism by which the pretreatment SW lithotripsy (SWL) protocol reduces tissue injury. MATERIALS AND METHODS: Female farm pigs (6-weeks-old) were anaesthetized with isoflurane and the lower pole of the right kidney treated with SWs using a conventional electrohydraulic lithotripter (HM3, Dornier GmbH, Germany). Pulsed Doppler ultrasonography was used to measure renal resistive index (RI) in blood vessels as a measure of resistance/impedance to blood flow. RI was recorded from one intralobar artery located in the targeted pole of the kidney, and measurements taken from pigs given sham SW treatment (Group 1; no SWs, four pigs), a standard clinical dose of high-energy SWs (Group 2; 2000 SWs, 24 kV, 120 SWs/min, seven pigs), low-energy SW pretreatment followed by high-energy SWL (Group3; 500 SWs, 12 kV, 120 SWs/min + 2000 SWs, 24 kV, 120 SWs/min, eight pigs) and low-energy SW pretreatment alone (Group 4; 500 SWs, 12 kV, 120 SWs/min, six pigs). RESULTS: Baseline RI (approximately 0.61) was similar for all groups. Pigs receiving sham SW treatment (Group 1) had no significant change in RI. A standard clinical dose of high-energy SWs (Group 2) did not significantly alter RI during treatment, but did increase RI at 45 min after SWL. Low-energy SWs did not alter RI in Group 3 pigs, but subsequent treatment with a standard clinical dose of high-energy SWs resulted in a significantly earlier (at 1000 SWs) and greater (two-fold) rise in RI than that in Group 2 pigs. This rise in RI during the low/high-energy SWL protocol was not due to a delayed vasoconstrictor response of pretreatment, as low-energy SW treatment alone (Group 4) did not increase RI until 65 min after SWL. CONCLUSIONS: The pretreatment protocol induces renal vasoconstriction during the period of SW application whereas the standard protocol shows vasoconstriction occurring after SWL. Thus, the earlier and greater rise in RI during the pretreatment protocol may be causally associated with a reduction in tissue injury.
机译：目的：测试肾脏预处理的假设，低能量冲击波（SWS）将诱导肾脏血管收缩，而不是标准临床剂量的高能量SWS，从而提供预处理SW Lithotripsy（SWL）的潜在机制）协议减少了组织损伤。材料和方法：雌性农场猪（6周龄）与异氟烷和使用常规电液型碎石（HM3，Dornier GmbH，Germany）用SWS处理的右肾的下极进行麻醉。脉冲多普勒超声检查用于测量血管中的肾电图指数（RI），作为对血流的抗性/阻抗的衡量标准。 Ri从位于肾脏的靶杆中的一个瘤内动脉记录，并从猪的测量鉴于假血管SW治疗（第1组;没有SWS，4只猪），一个标准的临床剂量的高能量SWS（第2组; 2000 SWS，24 kV，120瑞士/分钟/分钟，七只猪），低能量SW预处理，然后是高能量SWL（Group3; 500 SWS，12 kV，120 SWS / MIN + 2000 SWS，24 kV，120 SWS / min，仅八只猪）和单独的低能量SW预处理（第4组; 500 SWS，12 kV，120瑞斯/分钟，六只猪）。结果：所有组的基线RI（约0.61）相似。接受假血管卫生治疗（第1组）的猪在RI没有显着变化。一种标准的临床剂量的高能量SWS（第2组）在治疗期间没有显着改变RI，但在SWL后45分钟增加了RI。低能量SWS在第3次猪中没有改变RI，但随后用标准临床剂量的高能量SWS治疗导致较早的（在1000瓦斯）和更大（两倍）的升高而不是组2只猪。在低/高能量SWL协议期间RI的这种升高不是由于预处理的延迟血管收缩响应，因为单独的低能量SW处理（第4组）在SWL之后直到65分钟才增加RI。结论：预处理方案在SW应用期间诱导肾血管收缩，而标准方案显示SWL后发生的血管收缩。因此，预处理方案期间RI的较早和更大的升高可能是因子损伤的降低而导致的。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号