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首页> 外文期刊>BJU international >The aggressiveness of urinary tract urothelial carcinoma increases with the severity of chronic kidney disease.
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The aggressiveness of urinary tract urothelial carcinoma increases with the severity of chronic kidney disease.

机译：尿路尿路上皮癌的侵袭性随着慢性肾病的严重程度而增加。

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OBJECTIVE: To assess, in a retrospective cohort, urinary tract urothelial carcinoma (UT-UC) in patients with various stages of chronic kidney disease (CKD) and their clinicopathological features, as patients with end-stage renal disease (ESRD) have a higher incidence of UT-UC, but the relationship between early stages of CKD and characteristics of UT-UC are less well known. PATIENTS AND METHODS: The study included 267 patients with pathologically confirmed UT-UC from January 1994 to December 2006; all had a physical examination (blood pressure), and measurements of laboratory data (serum creatinine, serum haemoglobin) and pathological data. The glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease equation. Patients were divided into three groups by individual GFR (mL/min), i.e. >60 (no/mild CKD), 30-60 (CKD stage 3) and <30 (CKD stage 4/5). RESULTS: The CKD stages included 81 (30.3%) patients with none/mild CKD, 121 (45.3%) with CKD stage 3 and 65 (24.3%) with CKD stage 4/5. There was a significant and parallel increase in the frequency of UT-UC as CKD severity increased from none/mild CKD to stage 3 (11% vs 55%), and from CKD stage 3 to 4/5 (55% vs 71%; P < 0.05). Pathologically, the frequency of high-grade and high T stage UT-UC in patients with CKD stage 3 (90% and 35%, respectively) and CKD stage 4/5 (91% and 29%, respectively) were significantly greater than in the group with none/mild CKD (P < 0.001). Advanced age and more distant metastasis were independent risk factors for patient survival. CONCLUSION: The aggressiveness of UT-UC increased with the severity of CKD, and this might have important clinical consequences.
机译：目的：在慢性肾病（CKD）的各个阶段的患者中，评估尿路群，尿路尿路上皮癌（UT-UC）及其临床病理特征，作为患有终末期肾病（ESRD）的患者具有更高的患者UT-UC的发病率，但CKD的早期阶段与UT-UC的特征之间的关系较少。患者和方法：该研究包括1994年1月至2006年12月病于1994年至12月的病理证实UT-UC的267名患者;所有人都有身体检查（血压），以及实验室数据的测量（血清肌酐，血清血红蛋白）和病理数据。使用肾病等式的饮食改性来计算肾小球过滤速率（GFR）。患者通过单个GFR（mL / min），即60（NO / MID CKD），30-60（CKD阶段3）和<30（CKD第4/5阶段）分为三组。结果：CKD阶段包括81例（30.3％）NOT / MIDCKD，121（45.3％）的患者，CKD阶段3和65（24.3％），CKD阶段4/5。 ut-uc的频率随着CKD严重程度从无/轻度CKD增加到第3阶段（11％与55％），并且从CKD阶段3至4/5（55％Vs 71％; P <0.05）。病理上，CKD阶段3患者（分别为90％和35％）和CKD阶段4/5（分别为91％和29％）的患者中高级和高T阶段UT-UC的频率明显大于None / Mild CKD的组（P <0.001）。高龄和更远的转移是患者存活的独立风险因素。结论：UT-UC的侵略性随着CKD的严重程度而增加，这可能具有重要的临床后果。

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