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首页> 外文期刊>Cytokine >The relationship of cytomegalovirus (CMV) infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8 + T cells in human aging
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The relationship of cytomegalovirus (CMV) infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8 + T cells in human aging

机译：人体衰老过程中巨细胞病毒（CMV）感染与CD8 + T细胞循环IFN-α水平和IL-7受体α表达的关系

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The IL-7 receptor alpha (IL-7Rα) is the high affinity receptor for IL-7 which is essential for T cell homeostasis. We recently reported an age-associated expansion of human effector memory (EM) CD8 + T cells expressing IL-7Rα low (IL-7Rα low), which could be detrimental to hosts by occupying " immunological space" We investigated the potential mechanisms for this phenomenon, focusing on cytomegalovirus (CMV) infection and INF-α. In the elderly (age≥65), CMV infection was associated with a decreased frequency of na?ve CD8 + T cells as well as with an increased frequency of total EM and IL-7Rα low EM CD8 + T cells. However, in the young (age≤40), this viral infection was associated only with an increased frequency of IL-7Rα low EM CD8 + T cells. There was no association found between CMV immune status and plasma levels of IFN-α. In CMV-infected young and elderly people, INF-α levels had no correlation with the frequency of IL-7Rα low EM CD8 + T cells although this cytokine levels correlated with the frequency of IL-7Rα low CD45RA + EM CD8 + T cells in CMV-uninfected elderly people. Our findings suggest that the effect of CMV infection on the frequency of CD8 + T cell subsets may begin with IL-7Rα low EM CD8 + T cells and spread to other subsets with aging. Also, IFN-α could be associated with the expansion of IL-7Rα low CD45RA + EM CD8 + T cells in the CMV-uninfected elderly.
机译：IL-7受体α（IL-7Rα）是IL-7的高亲和力受体，这对T细胞稳态至关重要。我们最近报道了与年龄相关的人类效应记忆（EM）CD8 + T细胞表达IL-7Rα低（IL-7Rα低）的扩张，这可能通过占据“免疫空间”而对宿主有害。我们研究了这种潜在机制现象，主要针对巨细胞病毒（CMV）感染和INF-α。在老年人（年龄≥65岁）中，CMV感染与幼稚CD8 + T细胞的频率降低以及总EM和IL-7Rα低EM CD8 + T细胞的频率增加有关。但是，在年轻人（年龄≤40岁）中，这种病毒感染仅与IL-7Rα低EM CD8 + T细胞的频率增加有关。在CMV免疫状态和血浆IFN-α水平之间没有关联。在CMV感染的年轻人和老年人中，INF-α水平与IL-7Rα低EM CD8 + T细胞的频率无关，尽管该细胞因子水平与IL-7Rα低CD45RA + EM CD8 + T细胞的频率相关。未感染CMV的老年人。我们的发现表明，CMV感染对CD8 + T细胞亚群频率的影响可能始于IL-7Rα低EM CD8 + T细胞，并随着年龄的增长而扩散到其他亚群。同样，在未感染CMV的老年人中，IFN-α可能与IL-7Rα低CD45RA + EM CD8 + T细胞的扩增有关。

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