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Regulating the immune system via IL-15 transpresentation

机译:通过IL-15转座调节免疫系统

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Transpresentation has emerged as an important mechanism mediating IL-15 responses in a subset of lymphocytes during the steady state. In transpresentation, cell surface IL-15, bound to IL-15Rα is delivered to opposing lymphocytes during a cell-cell interaction. The events most dependent on IL-15 include the development and homeostasis of memory CD8 T cells, Natural Killer cells, invariant Natural Killer T cells, and intraepithelial lymphocytes. As lymphocyte development and homeostasis involve multiple steps and mechanisms, IL-15 transpresentation can have diverse roles throughout. Moreover, distinct stages of lymphocyte differentiation require IL-15 transpresented by different cells, which include both hematopoietic and non-hematopoietic cell types. Herein, we will describe the points where IL-15 transpresentation impacts these processes, the specific cells thought to drive IL-15 responses, as well as their role in the course of development and homeostasis.
机译:转态已成为稳定状态下介导淋巴细胞亚群中IL-15反应的重要机制。在转递过程中,与IL-15Rα结合的细胞表面IL-15在细胞与细胞的相互作用过程中被递送至相对的淋巴细胞。最依赖IL-15的事件包括记忆CD8 T细胞,自然杀伤细胞,不变的自然杀伤T细胞和上皮内淋巴细胞的发育和稳态。由于淋巴细胞的发育和体内平衡涉及多个步骤和机制,因此IL-15的转染在整个过程中可能具有多种作用。此外,淋巴细胞分化的不同阶段需要由不同细胞(包括造血和非造血细胞类型)转染的IL-15。在本文中,我们将描述IL-15转座影响这些过程的点,被认为可驱动IL-15反应的特定细胞,以及它们在发育和体内平衡过程中的作用。

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