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首页> 外文期刊>BJU international >Comparison of type I and II papillary renal cell carcinoma (RCC) and clear cell RCC.
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Comparison of type I and II papillary renal cell carcinoma (RCC) and clear cell RCC.

机译：I型和II乳头状肾细胞癌（RCC）和透明细胞RCC的比较。

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OBJECTIVE: To compare the pathological features of clear cell renal cell carcinoma (ccRCC) with papillary RCC (pRCC) and further differentiate type I and II pRCC as independent prognosticators for survival. PATIENTS AND METHODS: From September 1994 to February 2007 557 RCCs were treated and reviewed. All patients underwent radical nephrectomy or nephron-sparing surgery. We reviewed patient data and correlated RCC subtypes to tumour size, pathological stage, nuclear grade, and 5-year cancer-specific survival (CSS). pRCC was re-evaluated in to type I and II. The 2002 Tumour-Node-Metastasis and Fuhrman classifications were used. RESULTS: In all, 391 (70%) patients had ccRCC, 96 (17%) had pRCC, 34 (6%) had chromophobe RCC, seven (1%) had ductus Bellini RCC and 29 (5%) had unclassified RCC. Upon re-evaluation 34 patients had type I pRCC and 62 had type II. The pRCCs were significantly smaller than the ccRCCs, at a mean (sd) of 4.5 (2.5) cm vs 5 (2.9) cm (P = 0.013), and multifocal (25% vs 12%, P = 0.001). Whereas patients with ccRCC had significantly more primary metastases (12% vs 3%, P = 0.014). The mean (sd) follow-up was 42.3 (41.4) months. The 5-year CSS for M0 patients was 84% for ccRCC and 90% for pRCC (P = 0.573). At multivariate analyses predictors for 5-year CSS were only tumour size (hazard ratio, HR 2.6, P < 0.001), pathological stage (HR 3.9, P < 0.001) and nuclear grade (HR 2.7, P < 0.001). The type I and II pRCCs had significantly different lymphovascular invasion (LVI) and 5-year CSS rates (94% vs 74%, P = 0.03). CONCLUSIONS: The ccRCCs were significantly larger at diagnosis than the pRCCs. The histological subtype (pRCC vs ccRCC) had no impact on the 5-year CSS in multivariate analyses. The type I and II pRCCs had similar histopathological features except for a significant difference in LVI. However, the 5-year CSS was significantly different in type I and II pRCC.
机译：目的：比较乳头RCC（PRCC）透明细胞肾细胞癌（CCRCC）的病理特征，进一步区分I和II PRCC作为存活的独立预后剂。患者及方法：从1994年9月到2007年2月，557 RCCS进行处理和审查。所有患者均接受了根治性肾切除术或肾上腺味道手术。我们审查了患者数据和相关的RCC亚型，以肿瘤大小，病理阶段，核等级和5年癌症特异性生存（CSS）。 PRCC重新评估为I和II型。使用2002年肿瘤节点转移和FUHRMAN分类。结果：总共391名（70％）患者CCRCC，96（17％）有PRCC，34（6％）具有辐射rcc，七（1％）有Ductus Bellini RCC，29（5％）未被淘汰RCC。在重新评估后，34名患者有I型PRCC和62型型II型。 PRCCs显着小于CCRCCs，平均值（SD）为4.5（2.5）cm Vs 5（2.9）cm（p = 0.013），多焦点（25％Vs 12％，p = 0.001）。虽然CCRCC的患者具有显着的主要转移（12％Vs 3％，P = 0.014）。平均（SD）随访时间为42.3（41.4）个月。 M0患者的5年CSS为CCRCC的84％，PRCC为90％（P = 0.573）。在多变量分析中，5年CSS的预测因子仅为肿瘤大小（危害比，HR 2.6，P <0.001），病理阶段（HR 3.9，P <0.001）和核等级（HR 2.7，P <0.001）。 I型和II型PRCCs具有显着不同的淋巴血管侵袭（LVI）和5年的CSS率（94％vs 74％，P = 0.03）。结论：诊断的CCRCC显着大于PRCC。组织学亚型（PRCC VS CCRCC）对多元分析中的5年CSS没有影响。除了LVI的显着差异，I型和II型PRCCs具有类似的组织病理学特征。然而，5年的CSS在I和II型PRCC中具有显着差异。

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