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首页> 外文期刊>Biotechnology Progress >A bioinspired 3D shape olibanum-collagen-gelatin scaffolds with tunable porous microstructure for efficient neural tissue regeneration
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A bioinspired 3D shape olibanum-collagen-gelatin scaffolds with tunable porous microstructure for efficient neural tissue regeneration

机译：一种生物悬浮的3D形状橄榄胶 - 胶原蛋白 - 明胶支架，可调节多孔微观结构，用于高效神经组织再生

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摘要

There are a number of procedures for regeneration of injured nerves; however, tissue engineering scaffolds seems to be a promising approach for recovery of the functionality of the injured nerves. Consequently, in this study, olibanum-collagen-gelatin scaffolds were fabricated by freeze-cast technology. For this purpose, the olibanum and collagen were extracted from natural sources. The effect of solidification gradient on microstructure and properties of scaffolds was investigated. Scanning electron microscopy micrographs showed the formation of lamellar-type microstructure in which the average pore size reduced with an increase in freezing rate. According to the results, the prepared scaffolds at lower freezing rate showed a slight reduction in mechanical strength while the swelling and biodegradation ratio were increased due to the presence of larger pores and unidirectional channels. The composition of scaffolds and oriented microstructure improved cellular interaction. In addition, scaffolds with lower freezing rate exhibited promising results in terms of adhesion, spreading, and proliferation. In brief, the synthesized scaffolds at lower solidification rate have the potential for more in vitro and in vivo analyses to regeneration of neural defects.
机译：有许多程序对受伤神经进行再生;然而，组织工程支架似乎是恢复受伤神经功能的有希望的方法。因此，在本研究中，通过冻铸技术制造橄榄糖蛋白 - 明胶支架。为此目的，从天然来源中提取橄榄石和胶原蛋白。研究了研究凝固梯度对支架微观结构和性质的影响。扫描电子显微镜显微照片显示了层状微观结构的形成，其中平均孔径随着冷冻速率的增加而降低。根据结果​​，在较低的冷冻速率下制备的支架显示出机械强度的略微降低，而由于存在较大的孔和单向通道，肿胀和生物降解比率增加。支架和取向微观结构的组成改善了细胞相互作用。此外，具有较低冷冻速率的支架在粘附，扩散和增殖方面表现出有希望的结果。简而言之，较低凝固率下的合成支架具有更多体外和体内分析的潜力，以对神经缺陷进行再生。

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