• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biotechnology Progress >Tissue and organ decellularization in regenerative medicine
【24h】

Tissue and organ decellularization in regenerative medicine

机译：再生医学中的组织和器官脱细胞化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The advancement and improvement in decellularization methods can be attributed to the increasing demand for tissues and organs for transplantation. Decellularized tissues and organs, which are free of cells and genetic materials while retaining the complex ultrastructure of the extracellular matrix (ECM), can serve as scaffolds to subsequently embed cells for transplantation. They have the potential to mimic the native physiology of the targeted anatomic site. ECM from different tissues and organs harvested from various sources have been applied. Many techniques are currently involved in the decellularization process, which come along with their own advantages and disadvantages. This review focuses on recent developments in decellularization methods, the importance and nature of detergents used for decellularization, as well as on the role of the ECM either as merely a physical support or as a scaffold in retaining and providing cues for cell survival, differentiation and homeostasis. In addition, application, status, and perspectives on commercialization of bioproducts derived from decellularized tissues and organs are addressed. (c) 2018 American Institute of Chemical Engineers
机译：脱细胞化方法的进步和改善可归因于对移植组织和器官的日益增长的需求。在保持细胞外基质（ECM）的复杂超微结构的同时，没有细胞和遗传材料的脱细胞组织和器官可以用作随后嵌入细胞以进行移植的支架。它们有可能模仿靶向解剖部位的原生生理学。已经应用了来自各种来源的不同组织和器官的ECM。目前许多技术目前涉及脱细胞化过程，这些过程与他们自己的优缺点。本综述重点介绍了脱细胞化方法的最新发展，用于脱细胞化的洗涤剂的重要性和性质，以及ECM的作用，也是仅仅是物理支持或作为支架，在保留和提供细胞存活，分化和分化的提示中的脚手架稳态。此外，解决了衍生自脱细胞组织和器官的生物产物商业化的应用，现状和观点。 （c）2018美国化学工程研究所

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号