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Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges

机译:综述:输血医学中的红细胞体外产生:进步,前景和挑战

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摘要

In vitro generation of red blood cells (RBCs) has the potential to circumvent the shortfalls in global demand for blood for transfusion applications. The conventional approach for RBC generation has been from differentiation of hematopoietic stem cells (HSCs) derived from cord blood, adult bone marrow or peripheral blood. More recently, RBCs have been generated from human induced pluripotent stem cells (hiPSCs) as well as from immortalized adult erythroid progenitors. In this review, we highlight the recent advances to RBC generation from these different approaches and discuss the challenges and new strategies that can potentially make large-scale in vitro generation of RBCs a feasible approach.
机译:在体外产生红细胞(RBCS)具有潜力旨在规避全球对输血应用血液的不足。 RBC生成的常规方法已经来自源自脐带血,成人骨髓或外周血的造血干细胞(HSCs)的分化。 最近,RBC已经从人诱导的多能干细胞(HIPSC)以及永生化的成年红细胞祖细胞产生。 在这篇综述中,我们强调了从这些不同的方法中突出了RBC生成的进步,并讨论了可能使RBCS具有可行方法的大规模发电的挑战和新策略。

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