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首页> 外文期刊>Cytokine >Interleukin 10 mitigates the development of the zymosan-induced multiple organ dysfunction syndrome in mice.
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Interleukin 10 mitigates the development of the zymosan-induced multiple organ dysfunction syndrome in mice.

机译：白介素10减轻小鼠中由酵母聚糖诱导的多器官功能障碍综合症的发展。

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We investigated the effect of interleukin 10 on the development of zymosan-induced multiple organ dysfunction syndrome (MODS) and on plasma concentrations and production capacity of tumour necrosis factor (TNF)-alpha by peritoneal cells. Groups of C57BL/6 mice received a single intraperitoneal injection with zymosan, a cell wall component of Saccharomyces cerevisiae, at day 0. Daily doses of human recombinant interleukin 10 (IL-10: 10 or 50 microg/kg) were given intraperitoneally either starting directly before administration of zymosan (day 0), or 5 or 8 days after administration of zymosan. The animals were monitored for survival, condition, body weight and temperature. On day 12 all surviving animals were killed to obtain plasma, organs and peritoneal cells. Plasma concentrations of TNF-alpha and lipopolysaccharide-stimulated production of TNF-alpha by peritoneal cells were measured; organ weights were registered as an indicator for organ damage. IL-10 improves survival and clinical condition and also reduces organ damage, but only at the highest dose used and only when started simultaneously with the administration of zymosan. Circulating TNF-alpha concentrations 12 days after zymosan are not affected by any of the IL-10 schedules used. However, lipopolysaccharide-stimulated production of TNF-alpha by peritoneal cells is increased, in a dose- and time-dependent fashion. The anti-inflammatory cytokine IL-10 is able to attenuate the development of MODS in this model, but only when given simultaneously with zymosan, and in high dosages. Copyright 1999 Academic Press.
机译：我们调查了白介素10对酵母聚糖诱导的多器官功能不全综合征（MODS）的发展以及腹膜细胞对血浆浓度和肿瘤坏死因子（TNF）-α生产能力的影响。 C57BL / 6小鼠组在第0天接受腹膜内注射酵母菌（酿酒酵母的细胞壁成分）单次腹膜内注射。每天一次腹膜内注射人重组白介素10（IL-10：10或50微克/千克）。直接在施用zymosan之前（第0天），或在施用zymosan后5或8天。监测动物的存活，状况，体重和温度。在第12天，杀死所有存活的动物以获得血浆，器官和腹膜细胞。测量了腹膜细胞的血浆TNF-α浓度和脂多糖刺激的TNF-α产生。器官重量被记录为器官损伤的指标。 IL-10可以改善生存率和临床状况，还可以减少器官损伤，但是IL-10只能以最高剂量使用，并且只有在与酵母聚糖同时给药时才能开始。酵母聚糖后12天的循环TNF-α浓度不受所用的任何IL-10方案的影响。然而，腹膜细胞以脂多糖刺激的TNF-α产生以剂量和时间依赖性方式增加。在该模型中，抗炎细胞因子IL-10能够减弱MODS的发展，但仅在与酵母聚糖同时并以大剂量给药时才如此。版权所有1999，学术出版社。

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