THE PRESENCE OF CHEMOKINE (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-POSITIVE CELLS AND CHEMOKINE RECEPTOR (CCR5, CXCR3)-POSITIVE CELLS IN INFLAMED HUMAN GINGIVAL TISSUES.

Kabashima H; Yoneda M; Nagata K; Hirofuji T; Maeda K

首页> 外文期刊>Cytokine >THE PRESENCE OF CHEMOKINE (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-POSITIVE CELLS AND CHEMOKINE RECEPTOR (CCR5, CXCR3)-POSITIVE CELLS IN INFLAMED HUMAN GINGIVAL TISSUES.

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THE PRESENCE OF CHEMOKINE (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-POSITIVE CELLS AND CHEMOKINE RECEPTOR (CCR5, CXCR3)-POSITIVE CELLS IN INFLAMED HUMAN GINGIVAL TISSUES.

机译：炎症的人牙龈组织中存在趋化因子（MCP-1，MIP-1alpha，MIP-1beta，IP-10，RANTES）阳性细胞和趋化因子受体（CCR5，CXCR3）阳性细胞。

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Chemokines are said to be small peptides that are chemoattractants for leukocyte subpopulations within local inflammation sites. Gingival inflammation is characterized by infiltration of inflammatory mononuclear cells. The point of this study was to examine the presence or absence of chemokine-positive cells and chemokine receptor-positive cells by means of immunohistochemical methods in samples of gingival tissues obtained from patients with marginal periodontitis. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, (IFN-gamma)-inducible protein-10 (IP-10) and RANTES-producing cells were found to be present in inflamed human gingival tissues. In addition, CCR5- and CXCR3-positive cells were present. In contrast, no factor expression was observed in periodontally healthy gingival tissue. Our findings suggest that these chemokines may be responsible for modulating the process of infectious disease such as marginal periodontitis.

机译：趋化因子据说是小的肽，是局部炎症位点内白细胞亚群的化学吸引剂。牙龈炎症的特征在于炎性单核细胞的浸润。这项研究的重点是通过免疫组织化学方法检查从边缘性牙周炎患者获得的牙龈组织样品中趋化因子阳性细胞和趋化因子受体阳性细胞的存在与否。发现巨噬细胞趋化蛋白-1（MCP-1），巨噬细胞炎性蛋白（MIP）-1alpha，MIP-1beta，（IFN-γ）诱导蛋白10（IP-10）和产生RANTES的细胞存在于人牙龈组织发炎。另外，存在CCR5-和CXCR3-阳性细胞。相反，在牙周健康的牙龈组织中未观察到因子表达。我们的发现表明，这些趋化因子可能是调节诸如边缘性牙周炎等传染病过程的原因。

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《Cytokine》 |2002年第2期|共8页
作者
Kabashima H; Yoneda M; Nagata K; Hirofuji T; Maeda K;
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正文语种 eng
中图分类细胞生物学;
关键词
Positive; Cells; CCR5; IP-10; MIP-1beta; 细胞; MIP-1β;

机译：Positive;Cells;CCR5;IP-10;MIP-1beta;细胞;MIP-1β;

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1. THE PRESENCE OF CHEMOKINE (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-POSITIVE CELLS AND CHEMOKINE RECEPTOR (CCR5, CXCR3)-POSITIVE CELLS IN INFLAMED HUMAN GINGIVAL TISSUES. [J] . Kabashima H, Yoneda M, Nagata K, Cytokine . 2002,第2期

机译：炎症的人牙龈组织中存在趋化因子（MCP-1，MIP-1alpha，MIP-1beta，IP-10，RANTES）阳性细胞和趋化因子受体（CCR5，CXCR3）阳性细胞。
2. Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1alpha, MIP-1beta, and eotaxin) in patients with atopic dermatitis. [J] . Kaburagi Y, Shimada Y, Nagaoka T, Archives of dermatological research. . 2001,第7期

机译：特应性皮炎患者中CC趋化因子（RANTES，MCP-1，MIP-1alpha，MIP-1beta和嗜酸性粒细胞趋化因子）的产生增加。
3. Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES. [J] . Kim MS, Magno CL, Day CJ, Journal of cellular biochemistry. . 2006,第3期

机译：在用RANKL分化的真实人破骨细胞和MCP-1和RANTES分化的破骨细胞样细胞中诱导趋化因子和趋化因子受体CCR2b和CCR4。
4. Inhibitory Effects of Lipoteichoic Acid, a Gram Positive Bacterial Cell Wall Product, on Lps-Induced Adhesion Molecule Expression and Chemokine Generation from Lung Microvascular Endothelial Cells [C] . Anne Burke-Gaffnev, Kate Blease, Paul G. Hellewell NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：脂素酸的抑制作用，革兰氏阳性细菌细胞壁产品，对肺部微血管内皮细胞的LPS诱导的粘附分子表达和趋化因子产生
5. Non-redundant Requirement for CXCR3 Chemokine Receptor Signaling in Trafficking of Tumoricidal T cells across Tumor Vascular Barriers. [D] . Mikucki, Maryann Elizabeth. 2016

机译：CXCR3趋化因子受体信号转导跨肿瘤血管屏障贩运杀伤性T细胞的非冗余需求。
6. Infiltrating CD8+ T Cells in Oral Lichen Planus Predominantly Express CCR5 and CXCR3 and Carry Respective Chemokine Ligands RANTES/CCL5 and IP-10/CXCL10 in Their Cytolytic Granules [O] . Wakana Iijima, Haruo Ohtani, Takashi Nakayama, 2003

机译：口腔扁平苔藓中浸润的CD8 + T细胞主要表达CCR5和CXCR3并在其细胞裂解颗粒中携带相应的趋化因子配体RANTES / CCL5和IP-10 / CXCL10。
7. Infiltrating CD8+ T Cells in Oral Lichen Planus Predominantly Express CCR5 and CXCR3 and Carry Respective Chemokine Ligands RANTES/CCL5 and IP-10/CXCL10 in Their Cytolytic Granules [O] . Wakana Iijima, Haruo Ohtani, Takashi Nakayama, 2003

机译：在口服地衣平面下渗透CD8 + T细胞主要表达CCR5和CXCR3，并在其细胞分解颗粒中携带各自的趋化因子配体rantes / ccl5和IP-10 / CxCl10

THE PRESENCE OF CHEMOKINE (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-POSITIVE CELLS AND CHEMOKINE RECEPTOR (CCR5, CXCR3)-POSITIVE CELLS IN INFLAMED HUMAN GINGIVAL TISSUES.

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