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首页> 外文期刊>Cytokine >Cytokine gene expression--part of host defence in pulpitis.
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Cytokine gene expression--part of host defence in pulpitis.

机译：细胞因子基因表达-牙髓炎宿主防御的一部分。

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Analyses of cytokines mediating inflammatory reactions are key to understanding the etiopathology of various diseases. This study investigated differences in cytokine gene expression between pulps from healthy virgin teeth and from symptomatic vital teeth with severe caries lesions in a group of young, healthy individuals. The mRNA levels of IL-1alpha, IL-1beta, IL-6, IL-8, and IL-18 were measured concomitantly by quantitative real-time RT-PCR. IL-1alpha and IL-1beta were not expressed at significantly higher levels in symptomatic versus clinically healthy pulps, while the difference was significant for the other cytokines (log-rank test, P<0.05). A concordance test for independence revealed significant correlation between IL-1alpha and IL-1beta, and between IL-6, IL-8, and IL-18 mRNA levels (P<0.05). The cytokine-specific differences revealed a differential significance of gene expression in cytokine regulation. The hypothesis that increase of cytokine mRNA expression is part of host reaction in pulpitis was corroborated by our observation.
机译：介导炎症反应的细胞因子的分析是了解各种疾病的病因学的关键。这项研究调查了一组健康的年轻个体中健康初生牙齿和有严重龋齿症状的有生命牙齿的牙髓之间细胞因子基因表达的差异。通过定量实时RT-PCR同时测量IL-1α，IL-1β，IL-6，IL-8和IL-18的mRNA水平。有症状的纸浆中IL-1alpha和IL-1beta的表达水平不高于临床上健康的纸浆，而其他细胞因子的差异则显着（对数秩检验，P <0.05）。独立性的一致性测试显示IL-1alpha和IL-1beta之间以及IL-6，IL-8和IL-18 mRNA水平之间存在显着相关性（P <0.05）。细胞因子特异性差异揭示了基因表达在细胞因子调控中的差异性意义。我们的观察结果证实了细胞因子mRNA表达增加是牙髓炎宿主反应的一部分的假说。

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