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首页> 外文期刊>Cytokine >IL-9 increases the expression of several cytokines in activated mast cells, while the IL-9-induced IL-9 production is inhibited in mast cells of histamine-free transgenic mice.
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IL-9 increases the expression of several cytokines in activated mast cells, while the IL-9-induced IL-9 production is inhibited in mast cells of histamine-free transgenic mice.

机译：IL-9增加了活化的肥大细胞中几种细胞因子的表达，而无组胺的转基因小鼠的肥大细胞中IL-9诱导的IL-9产生受到抑制。

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摘要

Histamine and IL-9 are suspected to play an important role in the pathogenesis of asthmatic and allergic reactions. Mast cells store a large amount of histamine in their granules and are capable of producing different cytokines upon stimulation. In this study we show that mast cells stimulated by IL-9 and ionomycin or IL-9 and antigen-specific IgE/antigen express several cytokines at mRNA level, among them are IL-5, IL-4, IL-10, IL-9, IL-13, IL-1beta, IL-1Ra, IL-6 and MIF. Furthermore, both IL-9 and ionomycin are needed for the production of these cytokines in great quantities, which is mediated through the production of IL-1beta. Histamine-free mast cells respond by a markedly decreased IL-9 expression to this stimulation. Our results show that this IL-9-induced IL-9 production may result in a positive feedback loop in mast cells and the lack of histamine disturbs this loop, which may serve as an explanation for the reduced asthmatic symptoms, observed in histamine-free mice.
机译：组胺和IL-9被怀疑在哮喘和过敏反应的发病机理中起重要作用。肥大细胞在其颗粒中储存大量的组胺，并且能够在刺激时产生不同的细胞因子。在这项研究中，我们显示了IL-9和离子霉素或IL-9刺激的肥大细胞以及抗原特异性IgE /抗原在mRNA水平上表达几种细胞因子，其中包括IL-5，IL-4，IL-10，IL- 9，IL-13，IL-1β，IL-1Ra，IL-6和MIF。此外，大量产生这些细胞因子需要IL-9和离子霉素，这是通过产生IL-1β介导的。无组胺的肥大细胞通过这种刺激显着降低的IL-9表达来响应。我们的结果表明，这种由IL-9诱导的IL-9产生可能导致肥大细胞出现正反馈回路，而缺乏组胺会扰乱该回路，这可能解释了无组胺时哮喘症状减轻的原因。老鼠。

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