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首页> 外文期刊>Cytokine >Sendai virus induces various cytokines in human peripheral blood leukocytes: different susceptibility of cytokine molecules to low pH.
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Sendai virus induces various cytokines in human peripheral blood leukocytes: different susceptibility of cytokine molecules to low pH.

机译:仙台病毒在人外周血白细胞中诱导多种细胞因子:细胞因子分子对低pH的敏感性不同。

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Virus infection of cell cultures induces the synthesis of various cytokines which can either inhibit or stimulate virus replication. The Sendai virus induces large quantities of biologically active interferon (IFN-alphan3) in human peripheral blood leukocytes (hPBL) in vitro, as well as many other cytokines. The supernatants of Sendai virus-infected hPBL contained biologically active IFN-alphan3, significant amounts of immunogenic IFN-gamma, monokines (IL-1alpha, IL-beta, TNF-alpha), lymphokines (IL-6, TNF-beta), growth factor (PDGF-AB) and small concentrations of IL-2 and GM-CSF. The analysis of the influence of the Sendai virus inactivation by lowering pH 2.0 on the cytokine concentrations showed that IL-1alpha, TNF-alpha, TNF-beta and IFN-gamma are susceptible to acid conditions, while IFN-alphan3, IL-1beta, IL-6 and IL-2 concentrations remained unchanged. Copyright 1999 Academic Press.
机译:细胞培养物的病毒感染诱导了各种细胞因子的合成,这些细胞因子可以抑制或刺激病毒复制。仙台病毒在人外周血白细胞(hPBL)以及许多其他细胞因子中诱导大量生物活性干扰素(IFN-alphan3)。仙台病毒感染的hPBL的上清液含有生物活性IFN-αn3,大量的免疫原性IFN-γ,单核因子(IL-1alpha,IL-beta,TNF-alpha),淋巴因子(IL-6,TNF-beta),生长因子(PDGF-AB)和低浓度的IL-2和GM-CSF。降低pH 2.0对仙台病毒灭活对细胞因子浓度的影响分析表明,IL-1α,TNF-α,TNF-β和IFN-γ对酸性条件敏感,而IFN-αn3,IL-1β, IL-6和IL-2浓度保持不变。版权所有1999,学术出版社。

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