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首页> 外文期刊>Cytokine >TGF-beta1 gene polymorphisms influence the course of the disease in non-Hodgkin's lymphoma patients.
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TGF-beta1 gene polymorphisms influence the course of the disease in non-Hodgkin's lymphoma patients.

机译：TGF-beta1基因多态性影响非霍奇金淋巴瘤患者的病程。

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摘要

Non-Hodgkin's lymphomas (NHL) constitute a heterogenous group of mainly B-cell lymphoproliferative diseases with different patterns of clinical behaviour. Biological mechanisms leading to development of NHL are not clearly understood. Transforming growth factor-beta1 (TGF-beta1) influences B cell growth and development. The present study aimed to determine whether there is an association between the polymorphic features located within the TGF-beta1 gene in NHL patients and progression of the disease. Two single nucleotide polymorphisms at positions 869 T/C (Leu10Pro) and 915 G/C (Arg25Pro) in the precursor region of the TGF-beta1 gene were determined in 55 NHL patients and 50 healthy individuals by PCR-SSP technique using commercial primers. In univariate analysis the presence of TGF-beta1 high producer genotypes (T/T G/G or T/C G/G) was found to significantly associate with an increased number of extranodal sites (11/30 vs 3/25, p=0.035 for two or more extranodal sites in patients having or lacking the TGF-beta1 high producer genotype, respectively). TGF-beta1 high producer genotype together with other clinical and biological factors (patient sex and age, stage and aggressiveness of the disease, presence of B symptoms, serum LDH level) were subjected to multivariate logistic regression analyses for the number of extranodal sites. Multivariate analysis confirmed the role of TGF-beta1 high producer genotype as a risk factor of NHL manifestation in two or more extranodal sites (OR=7.217, p=0.043) in addition to histological aggressiveness of the disease (OR=4.302, p=0.057). TGF-beta1 gene polymorphisms were found to associate with the course of the disease in NHL patients. TGF-beta1 high producer genotype appeared as an independent risk factor of extranodal manifestation of the disease.
机译：非霍奇金淋巴瘤（NHL）构成主要由B细胞淋巴增生性疾病组成的异质性组，具有不同的临床行为模式。尚不清楚导致NHL发生的生物学机制。转化生长因子-beta1（TGF-beta1）影响B细胞的生长和发育。本研究旨在确定NHL患者TGF-beta1基因内的多态性特征与疾病进展之间是否存在关联。使用商业引物通过PCR-SSP技术在55名NHL患者和50名健康个体中确定了TGF-beta1基因前体区域中869 T / C（Leu10Pro）和915 G / C（Arg25Pro）位置的两个单核苷酸多态性。在单变量分析中，发现TGF-β1高生产者基因型（T / TG / G或T / CG / G）的存在与结外部位数量的增加显着相关（11/30 vs 3/25，p = 0.035） TGF-beta1高生产者基因型患者中两个或多个结外部位）。将TGF-β1高生产者基因型与其他临床和生物学因素（患者的性别和年龄，疾病的阶段和侵袭性，B症状的存在，血清LDH水平）一起进行多结点外数的Logistic回归分析。多变量分析证实，除了该病的组织学侵袭性外，TGF-beta1高生产者基因型还作为两个或多个结外部位NHL表现的危险因素（OR = 7.217，p = 0.043），具有一定的作用（OR = 4.302，p = 0.057） ）。在NHL患者中，发现TGF-beta1基因多态性与疾病进程有关。 TGF-beta1高生产者基因型似乎是该疾病结外表现的独立危险因素。

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