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首页> 外文期刊>Cytokine >Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing.
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Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing.

机译：在正常衰老中，CXC趋化因子CXCL10和CC趋化因子CCL2血清水平升高。

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摘要

No study has evaluated contemporaneously serum CXC and CC chemokines changes in normal ageing. Serum levels of CXCL10 (sCXCL10) (CXC) and CCL2 (sCCL2) (CC) prototype chemokines have been measured in 164 healthy subjects, from 10 to 79 years of age (82 males/82 females). By simple regression analysis, sCXCL10 and sCCL2 were significantly related with increasing age (r=0.32, p<0.001; r=0.31, p<0.0001, respectively), and with each other (r=0.30, p=0.0004). In a multiple linear regression model, only age and sCCL2 were significantly related to sCXCL10 levels (p<0.001); age and sCXCL10 were significantly related to sCCL2 levels (p<0.001). Subjects with high sCXCL10 levels (>150 pg/ml) were not significantly associated with those with high sCCL2 levels (>559 pg/ml). This study, performed in healthy subjects on an age gradient, demonstrates an increase of sCXCL10 and sCCL2 with advancing age; the differential increase of sCXCL10 or sCCL2 may reflect a general shift towards Th1 or Th2 cytokines pattern, respectively.
机译：尚无研究评估正常衰老过程中血清CXC和CC趋化因子的变化。在164位10至79岁的健康受试者中测量了CXCL10（sCXCL10）（CXC）和CCL2（sCCL2）（CC）原型趋化因子的血清水平（男性82位/女性82位）。通过简单的回归分析，sCXCL10和sCCL2与年龄增长（r = 0.32，p <0.001; r ​​= 0.31，p <0.0001）以及彼此之间（r = 0.30，p = 0.0004）显着相关。在多元线性回归模型中，只有年龄和sCCL2与sCXCL10水平显着相关（p <0.001）;年龄和sCXCL10与sCCL2水平显着相关（p <0.001）。高sCXCL10水平（> 150 pg / ml）的受试者与高sCCL2水平（> 559 pg / ml）的受试者无显着相关性。这项研究是在健康受试者的年龄梯度上进行的，结果表明sCXCL10和sCCL2随着年龄的增长而增加。 sCXCL10或sCCL2的差异增加可能分别反映了向Th1或Th2细胞因子模式的总体转变。

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