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首页> 外文期刊>Cytokine >CXCL5 gene polymorphisms are related to systemic concentrations and leukocyte production of epithelial neutrophil-activating peptide (ENA-78).
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CXCL5 gene polymorphisms are related to systemic concentrations and leukocyte production of epithelial neutrophil-activating peptide (ENA-78).

机译：CXCL5基因多态性与上皮中性粒细胞激活肽（ENA-78）的全身浓度和白细胞产生有关。

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摘要

Data exist linking elevated epithelial neutrophil activating peptide (ENA-78) concentrations with myriad inflammatory conditions. ENA-78 is encoded by the CXCL5 gene which has recently been shown to be polymorphic in nature (rs352046 and rs425535). No functional data on these polymorphisms exist. We investigated whether CXCL5 polymorphisms are associated with differences in plasma ENA-78 concentrations or leukocyte production of ENA-78 from cultured leukocytes in relatively healthy adults. We genotyped 114 adults for the above polymorphisms. Variant alleles at both loci were highly linked (D'=1, r2=0.94). The rs352046 variant allele was associated with significantly higher ENA-78 plasma concentrations. A genotype effect was also demonstrated for this polymorphism and leukocyte production of ENA-78. Both polymorphisms were predicted to have functional consequences by in silico analyses, with the rs352046 polymorphism found to occur at a transcription factor binding site for myeloid zinc finger proteins and the rs425535 polymorphism found to be located in an exon splicing enhancer site. Our findings add to the strength of CXCL5 as candidate gene in future disease-gene and pharmacogenetic association studies.
机译：存在将上皮中性粒细胞激活肽（ENA-78）浓度升高与多种炎症状况相关联的数据。 ENA-78由CXCL5基因编码，该基因最近被证明具有多态性（rs352046和rs425535）。没有关于这些多态性的功能数据。我们研究了CXCL5多态性是否与血浆ENA-78浓度差异或从相对健康的成年人中培养的白细胞产生的ENA-78的白细胞产生有关。我们对114位成年人进行了上述多态性的基因分型。两个基因座的变异等位基因高度相关（D'= 1，r2 = 0.94）。 rs352046变异等位基因与ENA-78血浆浓度明显升高有关。还证实了ENA-78的这种多态性和白细胞产生的基因型效应。通过计算机分析预测这两个多态性均具有功能性后果，发现rs352046多态性发生在髓样锌指蛋白的转录因子结合位点，而rs425535多态性位于外显子剪接增强子位点。我们的发现增加了CXCL5作为候选基因在未来疾病基因和药物遗传学关联研究中的实力。

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