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首页> 外文期刊>Cytokine >Effects of chronic exercise on cytokine production in white adipose tissue and skeletal muscle of rats.
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Effects of chronic exercise on cytokine production in white adipose tissue and skeletal muscle of rats.

机译：慢性运动对大鼠白色脂肪组织和骨骼肌细胞因子产生的影响。

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White adipose tissue (WAT) is a major source of production of cytokines involved in chronic diseases such as obesity, type 2 diabetes, and atherosclerosis. Long-term exercise has been proposed as a therapy to reduce chronic inflammation. We investigated here the influence of an intense exercise training (over 7 weeks) on several cytokine concentrations including interleukin 1 receptor antagonist (IL-1ra), IL-1beta, and IL-12 in serum, WAT, and skeletal muscle (SM) from non-obese rats. Two groups of 10 rats were investigated: one group was progressively trained (the two last weeks: 120min per day, 25m/min, 7% grade, 5 days per week) and the other age-matched group was used as a sedentary control. Compared to sedentary rats, weight gain was lower in the trained rats (P<0.01). In WAT, concentrations of IL-1ra, IL-1beta, and IL-12 were lower (P<0.001 for IL-1ra and IL-12, P<0.05 for IL-1beta) while they were higher in SM (P<0.01 for IL-1ra, P<0.001 for IL-1beta, P<0.05 for IL-12), and similar in serum. Significant correlations were noted between (i) body weight and WAT concentrations of IL-1ra, IL-1beta, and IL-12 (0.595, 0.450, and 0.481, respectively), (ii) body weight and IL-1beta concentration in SM (-0.526). We also observed significant negative correlations between WAT and SM concentrations of the three cytokines. We show here for the first time that intense exercise training with weight loss reduced concentrations of IL-1ra, IL-1beta, and IL-12 in WAT, while it increased them in SM. These results suggest that exercise could help reduce inflammation in WAT through mobilization of immune cells producing pro- and anti-inflammatory cytokines in SM.
机译：白色脂肪组织（WAT）是涉及肥胖，2型糖尿病和动脉粥样硬化等慢性疾病的细胞因子的主要生产来源。长期运动已被提议作为减轻慢性炎症的疗法。我们在这里调查了剧烈运动训练（超过7周）对几种细胞因子浓度的影响，包括血清，WAT和骨骼肌（SM）中的白介素1受体拮抗剂（IL-1ra），IL-1beta和IL-12。非肥胖大鼠。研究了10只大鼠的两组：一组进行逐步训练（最后两周：每天120分钟，25m / min，7％坡度，每周5天），另一组与年龄匹配的组用作久坐对照。与久坐的大鼠相比，受过训练的大鼠的体重增加较低（P <0.01）。在WAT中，IL-1ra，IL-1beta和IL-12的浓度较低（IL-1ra和IL-12的P <0.001，IL-1beta的P <0.05），而SM中的浓度较高（P <0.01对于IL-1ra，对于IL-1beta，P <0.001，对于IL-12，P <0.05），并且在血清中相似。 （i）体重和IL-1ra，IL-1beta和IL-12的WAT浓度（分别为0.595、0.450和0.481）之间存在显着相关性;（ii）SM中的体重和IL-1beta浓度（ -0.526）。我们还观察到三种细胞因子的WAT和SM浓度之间显着负相关。我们首次在这里表明，通过减肥进行激烈的运动训练可降低WAT中IL-1ra，IL-1beta和IL-12的浓度，而增加SM中的浓度。这些结果表明，运动可以通过动员产生SM中促炎和消炎细胞因子的免疫细胞来帮助减轻WAT中的炎症。

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