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首页> 外文期刊>Cytokine >Interleukin-2 serum levels variations in recent onset atrial fibrillation are related with cardioversion outcome.
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Interleukin-2 serum levels variations in recent onset atrial fibrillation are related with cardioversion outcome.

机译：最近发作的心房纤颤中白细胞介素2的血清水平变化与心脏复律结果相关。

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We evaluated the hypothesis that a relationship exists between inflammation and the outcome of pharmaceutical cardioversion with amiodarone in recent onset atrial fibrillation. We studied 86 patients with symptomatic recent onset AF and coexisting hypertension and/or chronic stable coronary artery disease. All study participants underwent evaluation with a standardized protocol including echocardiography, cytokine level measurement [interleukin-2 (IL-2), interleukin-6 (IL-6) and high sensitivity C reactive protein (hsCRP)] on admission and at 48h, and administration of intravenous amiodarone. By 48h, 70 patients cardioverted to sinus rhythm. Median serum IL-2 levels on admission were higher in non-cardioverted compared to cardioverted patients (P=0.002). At 48h, non-cardioverted had significantly higher IL-6 (P=0.005) and hsCRP values (P=0.001) compared to cardioverted. Multivariate logistic regression analysis showed that lower IL-2 admission levels were a powerful independent predictor for successfulcardioversion (OR: 0.154, 95% CI: 0.043-0.552, P=0.004). In patients with hypertension and/or chronic stable coronary artery disease and symptomatic recent onset AF, low serum IL-2 levels on admission are associated with successful cardioversion with amiodarone. This observation highlights the role of inflammation in AF and might have further prognostic and therapeutic implications.
机译：我们评估了以下假设：在近期发作的心房颤动中，炎症与胺碘酮药物复律的结果之间存在关系。我们研究了86例有症状的近期发作性AF和并存的高血压和/或慢性稳定冠状动脉疾病的患者。所有参加研究的受试者均在入院时和入院时以及入院时和入院时以及入院时和入院时以及入院时和入院时以及入院时和入院时以及入院后48h进行标准化的评估，包括超声心动图，细胞因子水平[白介素2（IL-2），白介素6（IL-6）和高敏C反应蛋白（hsCRP）]，静脉注射胺碘酮。到48小时时，有70名患者因窦性心律而心跳加快。非心脏过度手术的患者入院时血清IL-2水平高于心脏过度手术的患者（P = 0.002）。在第48小时，与心脏过度手术相比，非心脏过度手术具有更高的IL-6（P = 0.005）和hsCRP值（P = 0.001）。多元逻辑回归分析表明，较低的IL-2摄入水平是成功进行心脏复律的有力独立预测因子（OR：0.154，95％CI：0.043-0.552，P = 0.004）。在患有高血压和/或慢性稳定冠状动脉疾病和有症状的近期发作性AF的患者中，入院时血清IL-2水平低与胺碘酮的成功心脏复律有关。该观察结果突出了炎症在AF中的作用，并可能具有进一步的预后和治疗意义。

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