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首页> 外文期刊>Cytokine >Lens culinaris, Phaseolus vulgaris and vicia faba lectins specifically trigger IL-8 production by the human colon carcinoma cell line CACO-2.
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Lens culinaris, Phaseolus vulgaris and vicia faba lectins specifically trigger IL-8 production by the human colon carcinoma cell line CACO-2.

机译：扁豆，菜豆和蚕豆凝集素可特异性触发人结肠癌细胞系CACO-2产生IL-8。

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摘要

Cultured Caco-2 cells were stimulated with Lens culinaris, Phaseolus vulgarisandVicia fabalectins. The production of IL-1, IL-6, IL-8 and MCP-1 was measured by ELISA and RT-PCR. IL-8 production appeared to be specifically triggered upon stimulation with all three lectins used, since none of the other cytokines tested were produced. The IL-8 secreted may induce the extravasation of activated neutrophils and generate tissue damage. A similar mechanism may be implicated in the lesions observed after infection by some enteric pathogens, with lectin-like domains on their membrane. Finally, this model may be suitable one to study the regulation of IL-8 production. Copyright 2000 Academic Press.
机译：培养的Caco-2细胞用Lens culinaris，菜豆和野豌豆蚕豆刺激。通过ELISA和RT-PCR测量IL-1，IL-6，IL-8和MCP-1的产生。由于使用了所有三种凝集素刺激，IL-8的产生似乎是在特定刺激下触发的，因为没有其他测试的细胞因子产生。分泌的IL-8可能诱导活化的中性粒细胞渗出并产生组织损伤。类似的机制可能与某些肠道病原体感染后在其膜上具有凝集素样结构域的观察到的病变有关。最后，该模型可能适合研究IL-8产生的调节。版权所有2000学术出版社。

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