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首页> 外文期刊>Cytokine >Divergent cell-specific effects of activin-A on thymocyte proliferation stimulated by phytohemagglutinin, and interleukin 1beta or interleukin 6 in vitro.
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Divergent cell-specific effects of activin-A on thymocyte proliferation stimulated by phytohemagglutinin, and interleukin 1beta or interleukin 6 in vitro.

机译：在体外，激活素A对植物血凝素和白介素1beta或白介素6刺激的胸腺细胞增殖的不同细胞特异性作用。

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摘要

Activin-A is a member of the transforming growth factor-beta (TGF-beta) cytokine family. Based on studies in several cell systems, activin-A has been postulated to be a specific inhibitor of the actions of the inflammatory cytokine, interleukin 6. In cultures of adult rat thymocytes, activin-A inhibited sub-optimal phytohemagglutinin-induced and interleukin 1beta-stimulated proliferation, as measured by [(3)H]-thymidine incorporation in vitro. In contrast with TGF-beta1, which exerted similar inhibitory effects on thymocyte proliferation, activin-A activity was reduced by increasing the concentration of phytohemagglutinin or addition of the reducing agent, beta-mercaptoethanol. Both activin-A and TGF-beta1 inhibited the in vitro production of interleukin 6 by thymocytes in the presence of phytohemagglutinin and interleukin 1beta. In the presence of exogenous interleukin 6, however, both activin-A and TGF-beta1 stimulated thymocyte proliferation. These data suggest that activin-A inhibits thymocyte growth and differentiation, at least in part, by inhibiting endogenous production of interleukin 6, but stimulates thymocyte growth when exogenous interleukin 6 is present in vitro. These data indicate that activin interacts with other cytokines to exert complex regulation of T cell development, and is not an inhibitor of interleukin 6 action in all cell systems. Copyright 2000 Academic Press.
机译：激活素A是转化生长因子β（TGF-beta）细胞因子家族的成员。根据对多个细胞系统的研究，假定激活素A是炎性细胞因子白介素6的特异性抑制剂。在成年大鼠胸腺细胞的培养物中，激活素A抑制了次优的植物血凝素诱导和白介素1beta的作用。 -通过体外[（3）H]-胸腺嘧啶核苷的掺入量来刺激增殖。与对胸腺细胞增殖具有类似抑制作用的TGF-beta1相比，激活素A活性通过增加植物血凝素的浓度或添加还原剂β-巯基乙醇而降低。在存在植物血凝素和白介素1β的情况下，激活素A和TGF-β1均抑制了胸腺细胞对白细胞介素6的体外产生。但是，在存在外源白介素6的情况下，激活素A和TGF-beta1均可刺激胸腺细胞增殖。这些数据表明，激活素-A至少部分地通过抑制白细胞介素6的内源性产生来抑制胸腺细胞的生长和分化，但是当体外存在外源白介素6时，其刺激胸腺细胞的生长。这些数据表明，激活素与其他细胞因子相互作用以发挥对T细胞发育的复杂调节作用，而不是在所有细胞系统中都抑制白介素6的作用。版权所有2000学术出版社。

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