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首页> 外文期刊>Cytokine >Studies on toll-like receptor stimuli responsiveness in HIV-1 and HIV-2 infections.
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Studies on toll-like receptor stimuli responsiveness in HIV-1 and HIV-2 infections.

机译：研究HIV-1和HIV-2感染中的收费型受体刺激反应。

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BACKGROUND: HIV-1 and HIV-2 are two related viruses with distinct clinical outcomes, where HIV-1 is more pathogenic and transmissible than HIV-2. The pathogenesis of both infections is influenced by the dysregulation and deterioration of the adaptive immune system. However, their effects on the responsiveness of innate immunity are less well known. Here, we report on toll-like receptor (TLR) stimuli responsiveness in HIV-1 or HIV-2 infections. METHODS: Whole blood from 235 individuals living in Guinea-Bissau who were uninfected, infected with HIV-1, infected with HIV-2, and/or infected with HTLV-I, was stimulated with TLR7/8 and TLR9 agonists, R-848 and unmethylated CpG DNA. After TLR7/8 and TLR9 stimuli, the expression levels of IL-12 and IFN-alpha were related to gender, age, infection status, CD4(+) T cell counts, and plasma viral load. RESULTS: Defective TLR9 responsiveness was observed in the advanced disease stage, along with CD4(+) T cell loss in both HIV-1 and HIV-2 infections. Moreover, TLR7/8 responsiveness was reduced in HIV-1 infected individuals compared with uninfected controls. CONCLUSIONS: Innate immunity responsiveness can be monitored by whole blood stimulation. Both advanced HIV-1 and HIV-2 infections may cause innate immunity dysregulation.
机译：背景：HIV-1和HIV-2是两种具有不同临床结果的相关病毒，其中HIV-1比HIV-2更具致病性和传染性。两种感染的发病机理都受到适应性免疫系统失调和退化的影响。然而，它们对先天免疫反应性的影响尚不为人所知。在这里，我们报告在HIV-1或HIV-2感染中的收费样受体（TLR）刺激反应。方法：用TLR7 / 8和TLR9激动剂R-848刺激来自几内亚比绍的235名未感染，感染HIV-1，感染HIV-2和/或感染HTLV-1的个体的全血。和未甲基化的CpG DNA。在TLR7 / 8和TLR9刺激后，IL-12和IFN-α的表达水平与性别，年龄，感染状况，CD4（+）T细胞计数和血浆病毒载量有关。结果：在晚期疾病阶段观察到TLR9应答缺陷，在HIV-1和HIV-2感染中CD4（+）T细胞丢失。此外，与未感染的对照组相比，HIV-1感染者的TLR7 / 8反应性降低。结论：可以通过全血刺激来监测先天性免疫应答。晚期HIV-1和HIV-2感染都可能导致先天免疫失调。

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