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首页> 外文期刊>Cytokine >Maternal serum ADMA is not associated with proinflammatory cytokines or C-reactive protein during normal pregnancy.
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Maternal serum ADMA is not associated with proinflammatory cytokines or C-reactive protein during normal pregnancy.

机译：在正常怀孕期间，孕妇血清ADMA与促炎细胞因子或C反应蛋白无关。

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Normal pregnancy is associated with changes in the immune system. We studied whether asymmetrical dimethylarginine (ADMA) is associated with this immune system change by assaying high sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). The cytokine and dimethylarginine serum concentrations were determined from women with normal pregnancy (n=77) and healthy non-pregnant controls (n=61) matched for age and smoking status as a part of a large population-based, prospective cohort study conducted in Finland. The hsCRP levels were significantly elevated in the second (P=0.016) and third trimesters (P=0.001) of pregnancy compared to the levels of non-pregnant women. IL-6 levels were significantly higher in the third trimester (P=0.029) of pregnancy than in non-pregnant state. TNF-alpha concentrations did not change significantly during pregnancy. ADMA and SDMA concentrations were significantly lower during pregnancy compared to the levels of non-pregnant women (P<0.001). There was no significant association between ADMA and inflammation markers regardless of the elevated serum concentrations of hsCRP and IL-6 in the third trimester of normal pregnancy. These results suggest that maternal systemic ADMA and SDMA concentrations are more likely to become decreased due to the hemodilution and increased renal clearance than being directly influenced by the change of cytokines during pregnancy.
机译：正常怀孕与免疫系统的变化有关。我们通过测定高度敏感的C反应蛋白（hsCRP），白介素6（IL-6）和肿瘤坏死因子-α（TNF-α），研究了不对称二甲基精氨酸（ADMA）是否与这种免疫系统改变有关。这项研究是根据2004年进行的大规模人群前瞻性队列研究的一部分，从正常妊娠（n = 77）和健康的非妊娠对照组（n = 61）中根据年龄和吸烟状况确定的细胞因子和二甲基精氨酸血清浓度。芬兰。与未怀孕的妇女相比，在怀孕的第二（P = 0.016）和第三三个月（P = 0.001），hsCRP水平显着升高。妊娠中期（IL = 0.029）IL-6水平明显高于未妊娠状态。怀孕期间TNF-α浓度没有明显变化。与未怀孕妇女相比，怀孕期间的ADMA和SDMA浓度显着降低（P <0.001）。无论正常妊娠中期的hsCRP和IL-6血清浓度升高，ADMA与炎症标志物之间均无显着关联。这些结果表明，孕妇血液中的ADMA和SDMA全身浓度比直接受怀孕期间细胞因子变化直接影响的血液稀释和增加的肾脏清除率更可能降低。

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