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首页> 外文期刊>Cytokine >Host-pathogen interactions in the development of metabolic disturbances and atherosclerosis in HIV infection: the role of CCL2 genetic variants.
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Host-pathogen interactions in the development of metabolic disturbances and atherosclerosis in HIV infection: the role of CCL2 genetic variants.

机译：HIV感染中代谢紊乱和动脉粥样硬化发展过程中的宿主-病原体相互作用：CCL2基因变异的作用。

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BACKGROUND: Circulating CCL2 concentration has been implicated in promoting atherosclerosis in patients infected with HIV. We evaluated whether CCL2 gene variants are associated with metabolic disturbances and plasma CCL2 levels in HIV-infected patients. METHODS AND RESULTS: CCL2 genotypes and estimated haplotypes, plasma CCL2 levels and indicators of metabolic status in HIV-infected patients were compared with a representative group of the general population. We also performed a carotid/femoral artery ultrasonography to detect sub-clinical atherosclerosis in these patients. Six haplotypes were estimated in more than the 5% of individuals, and accounted for more than 98% of the population. In HIV-infected patients, carriers of H1, H2 and H5 haplotypes had higher CCL2 concentration than carriers of H3, H4 and H6 haplotypes. However, only carriers of H1 and H5 haplotypes presented higher insulin resistance as well as higher proportion of patients affected with sub-clinical. Conversely, carriers of H2 haplotype, which also showed high plasma CCL2 concentration, were associated with less deleterious metabolic disturbances. CONCLUSIONS: Our data are consistent with the hypothesis that the genetic background of the host is involved in CCL2 production and that this chemokine is implicated in promoting metabolic disturbances and sub-clinical atherosclerosis in HIV-infected patients.
机译：背景：循环中的CCL2浓度与促进HIV感染患者的动脉粥样硬化有关。我们评估了CCL2基因变异是否与HIV感染患者的代谢紊乱和血浆CCL2水平相关。方法和结果：将HIV感染患者的CCL2基因型和估计的单倍型，血浆CCL2水平和代谢状况指标与普通人群中的代表性人群进行了比较。我们还进行了颈/股动脉超声检查以检测这些患者的亚临床动脉粥样硬化。在超过5％的个体中，估计有六种单倍型，占总人口的98％以上。在感染HIV的患者中，H1，H2和H5单倍型携带者的CCL2浓度高于H3，H4和H6单倍型携带者。但是，只有H1和H5单倍型的携带者表现出更高的胰岛素抵抗以及亚临床感染患者的更高比例。相反，H2单倍型携带者，也显示出高血浆CCL2浓度，与有害的代谢紊乱相关。结论：我们的数据与假说有关，宿主的遗传背景与CCL2的产生有关，并且这种趋化因子与促进HIV感染患者的代谢紊乱和亚临床动脉粥样硬化有关。

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