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首页> 外文期刊>Cytokine >The interleukin-8-251 AA genotype is associated with angiogenesis in gastric carcinogenesis in Helicobacter pylori-infected Koreans.
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The interleukin-8-251 AA genotype is associated with angiogenesis in gastric carcinogenesis in Helicobacter pylori-infected Koreans.

机译：白细胞介素8-251 AA基因型与幽门螺杆菌感染的韩国人胃癌发生中的血管生成有关。

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摘要

Helicobacter pylori (H. pylori) is an important risk factor of gastric adenocarcinoma. Interleukin (IL)-8 is a potent angiogenic factor and plays an important role in inflammation of gastric mucosa by H. pylori. Host susceptibility may help to predict H. pylori-infected individuals with a higher risk of gastric adenocarcinoma. The aim of this study was to clarify the effect of IL-8 polymorphism on angiogenesis in the process of gastric carcinogenesis in H. pylori-infected Koreans. The IL-8-251A/T polymorphism was genotyped by PCR-RFLP from a total of 395 subjects; 92 normal controls, 87 H. pylori-infected controls, 108 chronic atrophic gastritis and/or intestinal metaplasia and 108 adenocarcinoma. The gastric mucosal concentrations of IL-8, membrane metalloproteinase (MMP)-9, angiopoietin (Ang)-1, and vascular endothelial growth factor (VEGF) were measured by ELISA. MMP-9 concentrations were increased with disease progression. There was significant correlation between MMP-9 and disease progression in AA (r=0.42, p<0.01) and AT genotype (r=0.43, p<0.01). Ang-1 concentrations were increased in AA genotype (r=0.40, p=0.01). However, there was no significant correlation between VEGF and disease progression in AA genotype. In conclusion, IL-8-251 AA genotype may be associated with angiogenesis in gastric carcinogenesis in H. pylori-infected Koreans.
机译：幽门螺杆菌（H. pylori）是胃腺癌的重要危险因素。白介素（IL）-8是有效的血管生成因子，在幽门螺杆菌引起的胃粘膜炎症中起重要作用。宿主易感性可能有助于预测幽门螺杆菌感染的个体患胃腺癌的风险更高。这项研究的目的是阐明IL-8多态性对感染幽门螺杆菌的韩国人胃癌发生过程中血管生成的影响。通过PCR-RFLP对总共395名受试者的IL-8-251A / T多态性进行基因分型。 92例正常对照，87例幽门螺杆菌感染对照，108例慢性萎缩性胃炎和/或肠化生以及108例腺癌。通过ELISA测量胃粘膜中IL-8，膜金属蛋白酶（MMP）-9，血管生成素（Ang）-1和血管内皮生长因子（VEGF）的浓度。 MMP-9浓度随疾病进展而增加。 MMP-9与AA（r = 0.42，p <0.01）和AT基因型（r = 0.43，p <0.01）的疾病进展之间存在显着相关性。 AA-1基因型中Ang-1浓度升高（r = 0.40，p = 0.01）。然而，在AA基因型中，VEGF与疾病进展之间没有显着相关性。总之，IL-8-251 AA基因型可能与幽门螺杆菌感染的韩国人胃癌发生中的血管生成有关。

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