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首页> 外文期刊>Cytokine >OX40 induces CCL20 expression in the context of antigen stimulation: an expanding role of co-stimulatory molecules in chemotaxis.
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OX40 induces CCL20 expression in the context of antigen stimulation: an expanding role of co-stimulatory molecules in chemotaxis.

机译：OX40在抗原刺激的情况下诱导CCL20表达：共刺激分子在趋化性中的扩展作用。

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OX40 is an inducible co-stimulatory molecule expressed by activated T cells. It plays an important role in the activation and proliferation of T lymphocytes. Recently, some co-stimulatory molecules have been shown to direct leukocyte trafficking. Chemotaxis is essential for achieving an effective immune response. CCL20 is an important chemoattractant produced by activated T cells. In this study, using DO11.10 mice whose transgenic T cell receptor specifically recognizes ovalbumin, we demonstrate that ovalbumin induces OX40 expression in CD4+ lymphocytes. Further stimulation of OX40 by OX40 activating antibody up-regulates CCL20 production. Both NF-kappaB dependent and independent signaling pathways are implicated in the induction of CCL20 by OX40. Finally, we primed the DO11.10 splenocytes with or without OX40 activating antibody in the presence of ovalbumin. Intranasal administration of the cell lysates derived from the cells with OX40 stimulation results in more severe leukocyte infiltration in the lung of DO11.10 mice, which is substantially attenuated by CCL20 blocking antibody. Taken together, this study has shown that activation of OX40 induces CCL20 expression in the presence of antigen stimulation. Thus, our results broaden the role of OX40 in chemotaxis, and reveal a novel effect of co-stimulatory molecules in orchestrating both T cell up-regulation and migration.
机译：OX40是由活化T细胞表达的诱导型共刺激分子。它在T淋巴细胞的活化和增殖中起重要作用。最近，一些共刺激分子已显示出指导白细胞运输的作用。趋化性对于实现有效的免疫反应至关重要。 CCL20是活化T细胞产生的重要化学吸引剂。在这项研究中，使用其转基因T细胞受体特异性识别卵白蛋白的DO11.10小鼠，我们证明卵白蛋白可诱导CD4 +淋巴细胞中OX40表达。 OX40激活抗体对OX40的进一步刺激会上调CCL20的产生。 OX40诱导CCL20涉及NF-κB依赖性和非依赖性信号通路。最后，我们在卵清蛋白存在下用或不用OX40激活抗体引发DO11.10脾细胞。经鼻腔给予源自OX40刺激的细胞的细胞裂解液会导致DO11.10小鼠的肺部出现更严重的白细胞浸润，而CCL20封闭抗体会大大减弱白细胞浸润。两者合计，这项研究表明，在抗原刺激下，OX40的激活可诱导CCL20表达。因此，我们的研究结果拓宽了OX40在趋化性中的作用，并揭示了协同刺激分子在协调T细胞上调和迁移中的新型作用。

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