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首页> 外文期刊>Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences >Simultaneous quantification of ligustilide, dl dl ‐3 ‐n‐ ‐n‐ butylphthalide and senkyunolide A in rat plasma by GC–MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction
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Simultaneous quantification of ligustilide, dl dl ‐3 ‐n‐ ‐n‐ butylphthalide and senkyunolide A in rat plasma by GC–MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction

机译：GC-MS在大鼠等离子体中同时定量Ligustilide，DL DL-3-N-叔丁基酞和Senkyonolide A及其对单独的川芎提取物的比较药代动力学研究及川芎汤汤

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Abstract The herb couple has special clinical significance in reducing the toxicity and increasing the efficacy of drugs. The combination of Radix Angelicae Dahuricae (Baizhi, BZ) and Rhizoma Chuanxiong (ChuanXiong, CX) is a traditional herb couple. The combination performs better than the CX extract alone in the treatment of migraine and has been used for thousands of years. However, the specific compatibility mechanisms are still unclear. Ligustilide, dl ‐3 ‐n‐ butylphthalide and senkyunolide A are the major active ingredients in CX and BZ–CX decoction. However, a comprehensive study of the pharmacokinetics of CX has not been carried out. A gas chromatography–mass spectroscopy (GC–MS) method with high selectivity, sensitivity and accuracy was developed. An SH‐Rxi‐5Sil (30?m?×?0.25?mm i.d., and 0.25?μm film thickness) column was employed in the GC separation. Selectivity, linearity, precision, accuracy, recovery, matrix effect and stability were used to validate the current GC–MS method. Using the validated method, this is the first time to study on the comparative pharmacokinetics of ligustilide, dl ‐3 ‐n‐ butylphthalide and senkyunolide A from CX alone and BZ–CX decoction in rat plasma. The pharmacokinetic parameters ( C max , T max , T 1/2 , AUC 0– t , AUC 0–∞ and CLz / F ) of all of the detected ingredients showed significant differences between the two groups ( P ??0.05). The results are helpful for further investigation of the compatibility mechanism of BZ–CX decoction.
机译：摘要草本植物夫妇在降低毒性和增加药物的疗效方面具有特殊的临床意义。 Gradix Angelicae Dahuricae（Baizhi，BZ）和Rhuanoma川芎（川芎，CX）的组合是传统草本夫妇。该组合在偏头痛的治疗中单独表现优于CX提取物，并已使用成千年。但是，具体的兼容机制仍然不清楚。 Ligustilide，DL -3 - 丁基苯二甲苯二甲酸和Senkyunolide A是CX和BZ-CX煎剂中的主要活性成分。然而，尚未进行对CX的药代动力学的综合研究。开发了一种具有高选择性，灵敏度和精度的气相色谱 - 质谱（GC-MS）方法。在GC分离中使用SH-RXI-5SIL（30≤M≤x≤0.25Ωme，和0.25μm膜厚度）塔。使用选择性，线性，精度，精度，恢复，矩阵效应和稳定性用于验证当前的GC-MS方法。使用验证的方法，这是第一次在大鼠等离子体中从CX和BZ-CX汤中从CX和BZ-CX煎剂中研究Ligustilide，DL-3 - 丁基苯二甲酸酯和Senkyonolide A的比较药代动力学。所有检测成分的药代动力学参数（C max，t max，t 1/2，AUC 0-T，AUC 0-χ和Clz / f）显示两组之间的显着差异（p≤≤0.05） 。结果有助于进一步调查BZ-CX汤剂的相容机制。

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