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A review of the herbal phosphodiesterase inhibitors; future perspective of new drugs.

机译：草药磷酸二酯酶抑制剂的综述;新药的未来前景。

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Phosphodiesterase inhibitors (PDEIs) are a class of drugs that are widely used because of their various pharmacological properties including cardiotonic, vasodilator, smooth muscle relaxant, antidepressant, antithrombotic, bronchodilator, antiinflammatory and enhancer of cognitive function. In the recent years, interest in drugs of plant origin has been progressively increased. Some pharmacologically active substances that come from plants demonstrate PDEI activity. They mainly belong to alkaloids, flavonoids, and saponins. In this review, studies on herbal PDEI were reviewed and their possible therapeutic applications were discussed. Screening plants for PDE inhibitory activity may help to develop standardized phytotherapeutic products or find new sources for new lead structures with PDEI pharmacological activity. The studies discussed in this paper are mainly in vitro and for more reasonable and conclusive results, it is required to conduct in vivo and finally human and clinical tests.
机译：磷酸二酯酶抑制剂（PDEIs）由于具有多种药理特性，包括强心药，血管扩张药，平滑肌松弛药，抗抑郁药，抗血栓药，支气管扩张药，抗炎药和认知功能增强剂，因此被广泛使用。近年来，对植物来源药物的兴趣逐渐增加。来自植物的一些药理活性物质表现出PDEI活性。它们主要属于生物碱，类黄酮和皂苷。在这篇综述中，对草药PDEI的研究进行了综述，并讨论了其可能的治疗应用。筛选植物的PDE抑制活性可能有助于开发标准化的植物治疗产品或寻找具有PDEI药理活性的新先导结构的新来源。本文讨论的研究主要是在体外，为了获得更合理和结论性的结果，需要进行体内以及最终的人体和临床试验。

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