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首页> 外文期刊>Blood purification >Medium Cut-Off Dialyzer versus Eight Hemodiafiltration Dialyzers: Comparison Using a Global Removal Score
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Medium Cut-Off Dialyzer versus Eight Hemodiafiltration Dialyzers: Comparison Using a Global Removal Score

机译：中截止透析仪与八个血液透析透析器：使用全球删除分数进行比较

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Background: A novel class of membranes, medium cut-off (MCO) membranes, has recently been designed to achieve interesting removal capacities for middle and large middle molecules in hemodialysis (HD) treatments. The few studies published to date have reported contradictory results regarding middle-sized molecules when comparing MCO dialyzers versus dialyzers used in online hemodiafiltration (OL-HDF). Methods: A prospective, single-center study was carried out in 22 patients. Each patient underwent 9 dialysis sessions with routine dialysis parameters, one with an MCO dialyzer in HD and the other 8 with different dialyzers in OL-HDF. The removal ratio (RR) of urea, creatinine, beta(2)-microglobulin, myoglobin, prolactin, alpha(1)-microglobulin, alpha(1)-acid glycoprotein, and albumin was intraindividually compared. Albumin loss in dialysate was measured. We propose a global removal score ([urea(RR) + beta(2)-microglobulin(RR) + myoglobin(RR) + prolactin(RR) + alpha(1)-microglobulin(RR) + alpha(1)-acid glycoprotein(RR)]/6 - albumin(RR)) as a new tool for measuring dialyzer effectiveness. Results: No significant differences in the RRs of small and middle molecular range molecules were observed between the MCO vs. OL-HDF dialyzers (range 60-80%). Lower RRs were found for alpha(1)-microglobulin and alpha(1)-acid glycoprotein without significant differences. The albumin RR was < 11% and dialysate albumin loss was < 3.5 g in all situations without significant differences. The global removal score was 54.9 +/- 4.8% with the MCO dialyzer without significant differences. Conclusions: Removal of a wide range of molecular weights, calculated with the proposed global removal score, was almost equal with the MCO dialyzer in HD treatment compared with 8 high-flux dialyzers in high-volume OL-HDF without relevant changes in albumin loss. The global removal score could be a new tool to evaluate the effectiveness of dialyzers and/or different treatment modalities.
机译：背景：最近设计了一种新颖的膜，中截止（MCO）膜，以实现血液透析（HD）治疗中的中大中分子的有趣去除能力。迄今为止发布的少数研究报告了在比较MCO透析器与在线血液透析（OL-HDF）中使用的透析器相比的中大分子的矛盾结果。方法：在22例患者中进行了前瞻性单中心研究。每位患者经过9个透析会话，常规透析参数，一个带有MCO透析器的HD和其他8个，在OL-HDF中具有不同的透析器。脲糖苷，肌蛋白，催乳素，催乳素，α（1） - 酸蛋白，α（1） - 酸糖蛋白，α（1）-ocid糖蛋白和白蛋白的去除率（RR）进行了分类。测量透析液中的白蛋白损失。我们提出了全局去除评分（[尿素（RR）+β（2）-microglobulin（RR）+肌球蛋白（RR）+催乳素（RR）+α（1） - 丙糊糊子蛋白（RR）+α（1） - 酸糖蛋白（RR）] / 6 - 白蛋白（RR））作为用于测量透析器效果的新工具。结果：在MCO与OL-HDF透析器（范围为60-80％）之间观察到小和中分子范围分子的RRS的显着差异。发现α（1）-microglobulin和α（1） - 酸糖蛋白没有显着差异的较低的RR。白蛋白RR在所有情况下<11％，透析液白蛋白损失<3.5g，没有显着差异。 MCO透析仪没有显着差异，全球去除分数为54.9 +/- 4.8％。结论：用所提出的全局去除评分除去各种分子量，与HD治疗中的MCO透析器几乎相等，与高体积OL-HDF中的8个高通量透析器相比，未经白蛋白损失的相关变化。全球去除分数可以是评估透析器和/或不同治疗方式的有效性的新工具。

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